KU0058948
National Institutes of Health
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Purpose: Pancreatic cancer is the fourth cause of death from cancer in the western world. Majority of patients present with…
Endometrioid endometrial cancer cell lines harboring PTEN loss of function have impaired homologous recombination response to DNA…
Poly(ADP-ribose) polymerases (PARPs) activate DNA repair mechanisms upon stress- and cytotoxin-induced DNA damage, and inhibition…
We have previously demonstrated that deficiency of either the BRCA1 or BRCA2 breast cancer susceptibility proteins confers…