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KU-596

 
National Institutes of Health

Papers overview

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2019
2019
Abstract Neuronal mitochondrial dysfunction and oxidative stress are key pathophysiologic mechanisms of diabetic peripheral… Expand
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2018
2018
Increased expression of the c-jun transcription factor occurs in a variety of human neuropathies and is critical in promoting… Expand
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2018
2018
KU-596 is a second-generation C-terminal heat shock protein 90 KDa (Hsp90) modulator based on the natural product, novobiocin. KU… Expand
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2018
2018
Heat shock protein 90 (Hsp90) is a chaperone under investigation for the treatment of cancer and neurodegenerative diseases… Expand
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2018
2018
Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes… Expand
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2017
2017
Heat Shock Protein 90 (Hsp90) is a molecular chaperone under clinical investigation for the treatment of neurodegenerative… Expand
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2017
2017
Neuronal mitochondrial dysfunction is a key pathophysiologic mechanism of diabetic peripheral neuropathy (DPN). KU-596 is a small… Expand
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2016
2016
KU-32 and KU-596 are novobiocin-derived, C-terminal heat shock protein 90 (Hsp90) modulators that induce Hsp70 levels and… Expand
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2015
2015
We have previously demonstrated that modulating molecular chaperones with KU-32, a novobiocin derivative, ameliorates physiologic… Expand
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2014
2014
Hsp90 represents a promising target for the development of both anti-cancer and neuroprotective agents. Structure-activity… Expand
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