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KU-596

National Institutes of Health

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2 relations

Broader (2)

GlycosidesPhenethylamines

Papers overview

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2020
2020
Synthesis of paramagnetic ligands that target the C-terminal binding site of Hsp90.
2019
2019
KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons
2018
2018
Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity.
2018
2018
Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects.
2018
2018
Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain.
Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes… 
2017
2017
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer.
2017
2017
Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy.
Increased expression of the c-jun transcription factor occurs in a variety of human neuropathies and is critical in promoting… 
2017
2017
Targeting Heat Shock Protein 70 to Improve Oxidative Stress and Mitochondrial Bioenergetics in Diabetic Sensory Neurons
Neuronal mitochondrial dysfunction is a key pathophysiologic mechanism of diabetic peripheral neuropathy (DPN). KU-596 is a small… 
2016
2016
Development of Noviomimetics as C-Terminal Hsp90 Inhibitors.
KU-32 and KU-596 are novobiocin-derived, C-terminal heat shock protein 90 (Hsp90) modulators that induce Hsp70 levels and… 
2014
2014
Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines.
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