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KS 119

Known as: KS-119, KS119 
National Institutes of Health

Papers overview

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2014
2014
Influence of Phosphate and Phosphoesters on the Decomposition Pathway of 1,2-Bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the Active Anticancer Moiety Generated by Laromustine, KS119, and…
Prodrugs of the short-lived chloroethylating agent 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine (90CE) and its methylating… 
2012
2012
Preliminary Studies with a New Hypoxia-Selective Cytotoxin, KS119W, In Vitro and In Vivo
Agents with selective toxicity to hypoxic cells have shown promise as adjuncts to radiotherapy. Our previous studies showed that… 
2011
2011
1,2‐Bis(methylsulfonyl)‐1‐(2‐chloroethyl)‐2‐[[1‐(4‐nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties
The anticancer prodrug 1,2‐bis(methylsulfonyl)‐1‐(2‐chloroethyl)‐2‐[[1‐(4‐nitrophenyl)ethoxy]carbonyl]hydrazine (KS119… 
Highly Cited
2005
Highly Cited
2005
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells.
To target malignant cells residing in hypoxic regions of solid tumors, we have designed and synthesized prodrugs generating the… 
2005
2005
An anticancer agent targeting hypoxic cells
To target malignant cells residing in hypoxic regions of solid tumors, we have designed and synthesized prodrugs generating the… 
2005
2005
Selective killing of hypoxic tumor cells by water soluble analogs of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119)
5888 Eradication of solid tumors requires strategies that address the viable populations of malignant cells within hypoxic… 
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