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KRT6A gene

Known as: CK6C, K6A, CK6D 
National Institutes of Health

Related topics

Related topics

3 relations
KRT6C geneKRT8 genekeratin 6A protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair
Keratin 6 negatively regulates Src kinase activity and the migratory potential of skin keratinocytes during wound repair. 
Highly Cited
2008
Highly Cited
2008
Single-nucleotide-specific siRNA targeting in a dominant-negative skin model.
RNA interference offers a novel approach for developing therapeutics for dominant-negative genetic disorders. The ability to… 
Highly Cited
2008
Highly Cited
2008
Development of therapeutic siRNAs for pachyonychia congenita.
Pachyonychia congenita (PC) is an autosomal-dominant keratin disorder where the most painful, debilitating aspect is plantar… 
Review
2005
Review
2005
The genetic basis of pachyonychia congenita.
In 1994, the molecular basis of pachyonychia congenita (PC) was elucidated. Four keratin genes are associated with the major… 
Highly Cited
2005
Highly Cited
2005
Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation*
Ubiquitin plays essential roles in various cellular processes; therefore, it is of keen interest to study the structure-function… 
Review
2003
Review
2003
The Molecular Genetics of Keratin Disorders
Keratins are the type I and II intermediate filament proteins which form a cytoskeletal network within all epithelial cells. They… 
Highly Cited
2001
Highly Cited
2001
Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita.
Thirteen patients with pachyonychia congenita types 1 and 2 were studied, two of which had a family history of pachyonychia and… 
Highly Cited
2001
Highly Cited
2001
Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b
The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b. These genes display a complex expression… 
Highly Cited
1998
Highly Cited
1998
A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2.
Type I and type II keratins form the heteropolymeric intermediate filament cytoskeleton, which is the main stress-bearing… 
Highly Cited
1995
Highly Cited
1995
Cloning and Characterization of Multiple Human Genes and cDNAs Encoding Highly Related Type II Keratin 6 Isoforms (*)
The human type II keratin 6 (K6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but… 
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