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Structure and function of desmosomes.
Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic intermediate filament cytoskeleton providing mechanical stability in epithelia and also in severalExpand
Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage
To examine the potential of cytoplasmic portions ("tails") of desmosomal cadherins for assembly of desmosome plaque structures and anchorage of intermediate filaments (IFs), we transfected culturedExpand
Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia
Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific functions, such asExpand
Structural and regulatory functions of keratins.
The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that are responsible to protect epithelial cells against mechanical stress and to act as signalingExpand
The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential
Plakoglobin is the only protein that occurs in the cytoplasmic plaques of all known adhering junctions and has been shown to be crucially involved in the formation and maintenance of desmosomesExpand
Loss of desmoglein 2 suggests essential functions for early embryonic development and proliferation of embryonal stem cells.
Desmoglein 2 (Dsg2) is a Ca(2+)-dependent adhesion molecule of desmosomes and is synthesized in all desmosome-bearing tissues from their earliest appearance onward. To examine the function of Dsg2,Expand
Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor
Removal of the entire keratin family of intermediate filament proteins from embryonic epithelia has surprising implications for mTOR signaling.
Mice lacking synaptophysin reproduce and form typical synaptic vesicles
Synaptophysin is one of the major integral membrane proteins of the small (30–50 nm diameter) electron-translucent transmitter-containing vesicles in neurons and of similar vesicles in neuroendocrineExpand
Identification of amino acid sequence motifs in desmocollin, a desmosomal glycoprotein, that are required for plakoglobin binding and plaque formation.
By transfecting epithelial cells with gene constructs encoding chimeric proteins of the transmembrane part of the gap junction protein connexin 32 in combination with various segments of theExpand
Characterization of the human gene encoding cytokeratin 17 and its expression pattern.
Among the members of the cytokeratin (CK) subfamily of intermediate filament (IF) proteins, CK 17 is remarkable as it is normally expressed in the basal cells of complex epithelia but not inExpand