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KRP 297

Known as: KRP-297, KRP297 
National Institutes of Health

Papers overview

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2006
2006
Absorption, Metabolism, and Excretion of [14C]MK-0767 (2-Methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) in Humans
MK-0767 (KRP-297; 2-methoxy-5-(2,4-dioxo-5-thiazolidinyl)-N-[[4-(trifluoromethyl)phenyl] methyl]benzamide) is a thiazolidinedione… 
2005
2005
Quantitative determination of a novel dual PPAR alpha/gamma agonist using on-line turbulent flow extraction with liquid chromatography-tandem mass spectrometry.
Turbulent flow chromatograph (TFC) is a technique for the direct and efficient analysis of drugs and metabolites in biological… 
2004
2004
A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR / AGONIST . II . IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
The in vitro metabolism of MK-0767 [( )-5-[(2,4-dioxothiazolidin-5-yl) methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl… 
2003
2003
Ragaglitazar: a novel PPAR alpha PPAR gamma agonist with potent lipid-lowering and insulin-sensitizing efficacy in animal models.
Ragaglitazar [(-) DRF 2725; NNC 61-0029] is a coligand of PPARalpha and PPARgamma. In ob/ob mice, ragaglitazar showed significant… 
Review
2003
Review
2003
MK-767. Kyorin/Banyu/Merck.
MK-767 (KRP-297, L-410198) is a peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma agonist under development… 
2003
2003
Synthesis of New Antidiabetic Agent KRP-297
Methyl 2 methoxy 5 nitrobenzoate underwent reduction, Meerwein arylation with ethyl acrylate, cyclization with thiourea… 
Review
2001
Review
2001
[KRP-297, MCC-555].
KRP-297 and MCC-555, which are being developed in Japan as thiazolidinediones, uniquely bind and activate peroxisome proliferator… 
2000
2000
Tissue-specific actions of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats.
1999
1999
Amelioration by KRP-297, a new thiazolidinedione, of impaired glucose uptake in skeletal muscle from obese insulin-resistant animals.
Highly Cited
1998
Highly Cited
1998
A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver…
We investigated the biological activity of a novel thiazolidinedione (TZD) derivative, KRP-297, and the molecular basis of this… 
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