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- Publications
- Influence
Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
- S. Rajagopal, R. Kumar, Dhanvanthri S. Deevi, Chitkala Satyanarayana, R. Rajagopalan
- Biology, Medicine
- Journal of experimental therapeutics & oncology
- 1 May 2003
Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological… Expand
Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)
- V. Aravindhan, V. Mohan, +7 authors S. Babu
- Medicine
- PLoS neglected tropical diseases
- 1 June 2010
Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF… Expand
Antidiabetic and hypolipidemic activity of Helicteres isora in animal models.
- R. Chakrabarti, R. Vikramadithyan, +5 authors R. Rajagopalan
- Biology, Medicine
- Journal of ethnopharmacology
- 1 August 2002
Helicteres isora (Sterculiaceae) root juice has been used in the treatment of diabetes by several ethnic groups in different parts of India. A program was initiated to elucidate the scientific basis… Expand
Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives.
- G. R. Madhavan, R. Chakrabarti, +8 authors R. Rajagopalan
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 August 2002
A series of pyrimidinone derivatives of thiazolidinediones were synthesized. Their biological activity were evaluated in insulin resistant, hyperglycemic and obese db/db mice. In vitro PPARgamma… Expand
DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells
- Chitkala Satyanarayana, Dhanavanthri S Deevi, R. Rajagopalan, N. Srinivas, S. Rajagopal
- Medicine
- BMC Cancer
- 18 June 2004
BackgroundWe determined the effect of andrographolide and one of its novel semi-synthetic analog, DRF 3188, on the cell cycle of MCF 7 breast cancer cells.MethodsThe effect of the compounds on cell… Expand
Diuretic Effects, Pharmacokinetics, and Safety of a New Centrally Acting Kappa‐Opioid Agonist (CI‐977) in Humans
- P. Reece, A. Sedman, S. Rose, D. S. Wright, R. Dawkins, R. Rajagopalan
- Medicine
- Journal of clinical pharmacology
- 1 November 1994
The diuretic effects, pharmacokinetics, and safety of CI‐977, a new centrally acting selective kappa‐opioid agonist, were determined in 16 healthy subjects. Subjects received single intramuscular… Expand
Posttonsillectomy pain relief and epithelialization with honey
- P. Letchumanan, R. Rajagopalan, M. Y. Kamaruddin
- Medicine
- 1 May 2013
To assess the ability of honey to reduce pain and promote epithelialization on posttonsillectomy wounds. Materials and methods: A prospective randomized control study was conducted on 60 patients… Expand
Synthesis and Biological Activity of Novel Thiazolidinediones.
- C. Prabhakar, G. Madhusudhan, +7 authors R. Rajagopalan
- Chemistry
- 9 February 1999
Diabetes and insulin resistance associated disorders: Disease and the therapy
- R. Chakrabarti, R. Rajagopalan
- Biology
- 10 May 2002
An overwhelming increase in metabolic syndrome, i.e., obesity, insulin resistance and dyslipidemia has led to type 2 or insulin-resistant diabetes mellitus assuming epidermic proportions. Currently,… Expand
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Novel euglycemic and hypolipidemic agents. 4. Pyridyl- and quinolinyl-containing thiazolidinediones.
- B. Lohray, V. Bhushan, +8 authors K. Katneni
- Chemistry, Medicine
- Journal of medicinal chemistry
- 22 June 1999
A series of substituted pyridyl- and quinolinyl-containing 2, 4-thiazolidinediones having interesting cyclic amine as a linker have been synthesized. Both unsaturated thiazolidinediones 5 and… Expand
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