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KRN 2391

Known as: KRN-2391, KRN2391 
National Institutes of Health

Papers overview

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1993
1993
Hemodynamic Profile of KRN2391, a Novel Vasodilator, in Anesthetized Dogs
In the present study, we compared the effects of KRN2391 (N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide… 
1993
1993
Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide‐sensitive K+ currents in Xenopus oocytes
1 The novel K+ channel opener, Y‐26763 induced outward K+ currents in voltage‐clamped follicle‐enclosed Xenopus oocytes in a… 
1993
1993
Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin‐1 in anaesthetized rats
1 The effect of KRN2391, a novel vasodilator, on the changes of electrocardiogram caused by endothelin‐1 (ET‐1) was studied in… 
1993
1993
Mechanism of action of KRN2391 in canine coronary vascular bed.
The present studies were performed to clarify the mechanism of action of KRN2391 in various sizes of canine coronary artery. We… 
1993
1993
Comparison of the effects of KRN2391 and other coronary dilators on porcine isolated coronary arteries of different sizes
Abstract— The present study was performed to determine whether KRN2391 (N‐cyano‐N′‐(2‐nitroxyethyl)‐3‐pyridinecarboximidamide… 
1993
1993
Comparison of the anti-vasoconstrictor effects of a novel vasodilator KRN2391, nicorandil and nifedipine on isolated porcine large coronary artery.
The anti-vasoconstrictor profile of KRN2391, a novel vasodilator, was compared with that of nicorandil and nifedipine in isolated… 
1992
1992
Comparison of KRN2391 with Nicorandil and Nifedipine on Canine Coronary Blood Flow: Antagonism by Glibenclamide
Summary: The mode of action of KRN2391 [N-cyano-N‘-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulfonate] in coronary… 
1992
1992
Contribution of cyclic GMP formation to KRN2391‐induced relaxation in coronary artery of the pig
1 In the present study, we investigated the relationship between relaxation and guanosine 3′:5′‐cyclic monophosphate (cyclic GMP… 
1992
1992
Comparative cardiovascular effects of KRN2391 and other coronary vasodilators in anesthetized open-chest dogs.
The effect of KRN2391 [N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulfonate] on the cardiovascular system… 
1991
1991
An analysis of the nitrate‐like and K channel opening actions of KRN2391 in canine coronary arterial smooth muscle
1 To clarify the mechanism of action of KRN2391, a new vasodilator containing a nitroxy group, its effects on intracellular Ca2… 
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