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KRN 2391

Known as: KRN-2391, KRN2391 
National Institutes of Health

Papers overview

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2008
2008
Inhibitory effects of nicorandil, a KATP channel opener and a nitric oxide donor, on overactive bladder in animal models
To investigate the effects of nicorandil, an ATP‐sensitive potassium (KATP) channel opener with a nitric oxide (NO) donor… Expand
1993
1993
Effect of KRN2391, a novel vasodilator, on various experimental anginal models in rats.
The antianginal effect of KRN2391, N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulfonate, on various anginal… Expand
1993
1993
Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide‐sensitive K+ currents in Xenopus oocytes
1 The novel K+ channel opener, Y‐26763 induced outward K+ currents in voltage‐clamped follicle‐enclosed Xenopus oocytes in a… Expand
1993
1993
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes
1 The relaxant mechanisms of action of KRN2391, a novel vasodilator, and nicorandil on epi‐myocardial coronary artery (2.5–3.0 mm… Expand
1993
1993
Hemodynamic Profile of KRN2391, a Novel Vasodilator, in Anesthetized Dogs
In the present study, we compared the effects of KRN2391 (N-cyano-N'-(2-nitroxyethyl)-3-pyridinecarboximidamide… Expand
1992
1992
Blockade by antiarrhythmic drugs of glibenclamide‐sensitive K+ channels in Xenopus oocytes
1 The outward K+ current induced by KRN2391 (K+ channel opener) in Xenopus oocytes is blocked by glibenclamide. We have… Expand
1992
1992
Comparison of KRN2391 with Nicorandil and Nifedipine on Canine Coronary Blood Flow: Antagonism by Glibenclamide
Summary: The mode of action of KRN2391 [N-cyano-N‘-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulfonate] in coronary… Expand
1991
1991
Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart.
Abstract The cardioprotective effect of KRN2391 (N-cyano-N-(2-nitroxymethyl)-3-pyridinecarboximidamide methanesulfonate), a novel… Expand
1991
1991
An analysis of the nitrate‐like and K channel opening actions of KRN2391 in canine coronary arterial smooth muscle
1 To clarify the mechanism of action of KRN2391, a new vasodilator containing a nitroxy group, its effects on intracellular Ca2… Expand
1991
1991
Characteristics of KRN2391, a novel vasodilator, compared with those of cromakalim, pinacidil and nifedipine in rat aorta.
The characteristics of KRN2391, a novel vasodilator, were studied in rat isolated aorta. The effects of KRN2391, cromakalim… Expand
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