KRAS NP_004976.2:p.G13X

Known as: GTPase KRas G13X, KRAS G13 Mutation, KRAS p.Gly13Xxx 
A change in the amino acid residue at position 13 in the GTPase KRas protein where glycine has been replaced by another amino acid.
National Institutes of Health

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Kras gene mutation

Papers overview

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Highly Cited
2014
Highly Cited
2014
Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer.
BACKGROUND The Panitumumab Randomized trial In combination with chemotherapy for Metastatic colorectal cancer to determine… (More)
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2014
2014
KRAS mutation influences recurrence patterns in patients undergoing hepatic resection of colorectal metastases.
BACKGROUND The validity of the KRAS mutation as a predictor of recurrence-free survival (RFS) or overall survival (OS) is unclear… (More)
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Highly Cited
2013
Highly Cited
2013
A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.
BACKGROUND & AIMS Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), but it is not clear how obesity… (More)
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2012
2012
Relationship between 18F-fluorodeoxyglucose accumulation and KRAS/BRAF mutations in colorectal cancer.
PURPOSE Positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) has been widely used in the management of… (More)
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Highly Cited
2011
Highly Cited
2011
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.
BACKGROUND The randomized phase II OPUS (Oxaliplatin and Cetuximab in First-Line Treatment of Metastatic Colorectal Cancer) study… (More)
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Highly Cited
2011
Highly Cited
2011
A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer.
PURPOSE Colorectal cancer (CRC) is a common cause of death worldwide. Tumor-node-metastasis-system stage is currently used to… (More)
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2011
2011
A randomized phase II/III study of the anti-IGF-1R antibody MK-0646 (dalotuzumab) in combination with cetuximab (Cx) and irinotecan (Ir) in the treatment of chemorefractory metastatic colorectal…
3501 Background: Evidence of cross-talk between EGFR and IGFR signaling pathways provide a logical rationale for combining anti… (More)
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Highly Cited
2010
Highly Cited
2010
Three DNA methylation epigenotypes in human colorectal cancer.
PURPOSE Whereas the CpG island methylator phenotype (CIMP) in colorectal cancer associates with microsatellite instability (MSI… (More)
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Highly Cited
2010
Highly Cited
2010
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS
Synergism between the RAS and Hedgehog (HH) pathways has been suggested for carcinogenesis in the pancreas, lung and colon. We… (More)
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2007
2007
Molecular analysis of colorectal cancer tumors from patients with mismatch repair proficient hereditary nonpolyposis colorectal cancer suggests novel carcinogenic pathways.
PURPOSE A subset of colorectal cancers (CRC) arises in families that, despite fulfilling clinical criteria for hereditary… (More)
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