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KPT-276

National Institutes of Health

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AcrylamidesThiazoles

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2015
2015
The end of the line for neutrophils.
In this issue of Blood , Bartels and colleagues demonstrate that acetylation of the transcription factor CCAAT enhancer binding… 
2013
2013
Abstract 2142: The nuclear export protein CRM1 (XPO1) regulates multiple myeloma cell growth, osteoclastogenesis, and myeloma-induced osteolysis.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC The key nuclear export protein CRM1 (chromosomal… 
2012
2012
Abstract LB-232: Preliminary results of a phase I study of the novel CRM1 inhibitors KPT-276 and KPT-335 in dogs with spontaneous cancer
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Introduction: KPT-276 and KPT-335 are irreversible… 
2012
2012
Genome Wide Studies in Multiple Myeloma Identify XPO1/CRM-1 As a Critical Target Validated Using the Selective Inhibitor of Nuclear Export (SINE) KPT-276
Abstract 573 Using high throughput RNA interference screening on 6,722 druggable genes we previously identified XPO1/CRM1 as one… 
2012
2012
Abstract 1825: Novel small molecule CRM-1 inhibitor for Non Hodgkin's Lymphoma
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Recent evidence demonstrates that Non Hodgkin's… 
2011
2011
Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma
Abstract 598 Recent evidence demonstrates that Non Hodgkin9s Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that… 
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