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KPT-251

 
National Institutes of Health

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OxadiazolesTriazoles

Papers overview

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2015
2015
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
Background and aimsIncreased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with poor… Expand
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2015
2015
Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
Background and aims: Increased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with… Expand
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2014
2014
Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer
Chromosome maintenance region 1 (CRM1) also called Exportin 1 (Xpo1), a protein found elevated in pancreatic ductal… Expand
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Highly Cited
2013
Highly Cited
2013
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.
PURPOSE Renal cell carcinoma often presents asymptomatically and patients are commonly diagnosed at the metastatic stage, when… Expand
2013
2013
Abstract 3440: CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce the incidence of tumor spreading and improve overall survival in preclinical models of prostate cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: CRM1 (XPO1) is the exclusive exportin… Expand
Highly Cited
2013
Highly Cited
2013
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as… Expand
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Highly Cited
2013
Highly Cited
2013
CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
Resistance to BRAF inhibitor therapy places priority on developing BRAF inhibitor-based combinations that will overcome de novo… Expand
2012
2012
Abstract 1815: CRM-1 as a potential therapeutic target in pancreatic cancer
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL CRM-1 exportin protein encoded by the XPO-1 gene… Expand
2012
2012
Abstract 1825: Novel small molecule CRM-1 inhibitor for Non Hodgkin's Lymphoma
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Recent evidence demonstrates that Non Hodgkin's… Expand
2011
2011
Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma
Abstract 598 Recent evidence demonstrates that Non Hodgkin9s Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that… Expand
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