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KPT-251

National Institutes of Health

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OxadiazolesTriazoles

Papers overview

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2016
2016
Erratum to: KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
2015
2015
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
Background and aimsIncreased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with poor… 
2015
2015
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
Increased expression of Chromosome Region Maintenance (CRM-1)/exportin-1 (XPO-1) has been correlated with poor prognosis in… 
Highly Cited
2013
Highly Cited
2013
CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.
2013
2013
Abstract 3440: CRM1-Selective Inhibitors of Nuclear Export (SINE) reduce the incidence of tumor spreading and improve overall survival in preclinical models of prostate cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: CRM1 (XPO1) is the exclusive exportin… 
Highly Cited
2013
Highly Cited
2013
CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
Resistance to BRAF inhibitor therapy places priority on developing BRAF inhibitor-based combinations that will overcome de novo… 
2012
2012
Abstract 1825: Novel small molecule CRM-1 inhibitor for Non Hodgkin's Lymphoma
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Recent evidence demonstrates that Non Hodgkin's… 
2012
2012
Abstract 1815: CRM-1 as a potential therapeutic target in pancreatic cancer
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL CRM-1 exportin protein encoded by the XPO-1 gene… 
Highly Cited
2012
Highly Cited
2012
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells
Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1 protein (CRM1) have potential as… 
2011
2011
Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma
Abstract 598 Recent evidence demonstrates that Non Hodgkin9s Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that… 
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