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KPT-185

National Institutes of Health

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Papers overview

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2015
2015
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating… 
2013
2013
Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase (AID)
We read with great interest the recent paper by Azmi et al. [1][1] who reported the in vitro and in vivo anti-lymphoma activity… 
2013
2013
Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: “Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for…
We read an enlightening piece of work from Shivarov and colleagues on the downstream secondary effects of CRM1 inhibition that… 
2013
2013
Abstract 5541: Therapeutic targeting of CRM1 in ovarian cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: CRM1 is a nuclear export protein which… 
2013
2013
Abstract 2163: Increased overall survival in platinum-resistant ovarian cancer: paradigmatic use of novel SINE (selective inhibitor of nuclear export), which restores p53 nuclear localization and…
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Ovarian cancer (OvCa) is the most lethal female… 
2012
2012
Molecular Mechanisms of Antitumor Activity of the Selective Inhibitor of Nuclear Export (SINE) CRM1 Antagonist KPT-185 in Mantle Cell Lymphoma.
Abstract 2438 CRM1, a member of the importin b super family of nuclear transport receptors, functions as a major nuclear export… 
2012
2012
Novel small-molecule CRM-1 inhibitor for GI cancer therapy.
245 Background: Pancreatic (PC) and Colon (CC) cancer remain deadly diseases despite the advent of novel targeted and cytotoxic… 
2012
2012
Kidney cancer: CRM1—a novel drug target for renal cell carcinoma?
Selective inhibitors of chromosome region maintenance protein 1 (CRM1) might provide therapeutic benefit for patients with renal… 
2011
2011
Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple…
Abstract 2913 CRM1 (chromosomal region maintenance 1, XPO1) is the major export protein regulating degradation of key tumor… 
2011
2011
Development of a Novel Small Molecule CRM-1 Inhibitor for Non Hodgkin's Lymphoma
Abstract 598 Recent evidence demonstrates that Non Hodgkin9s Lymphoma (NHL) tumors have elevated expression of the XPO1 gene that… 
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