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Pooled normal human polyspecific IgM contains neutralizing anti-idiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease.
It is shown that poolednormal human IgM (IVIgM) purified from plasma of more than 2,500 healthy donors and processed in a similar fashion to that of therapeutic preparations of pooled normal human IgG (IVG) suppresses activity of IgG autoantibodies purified from the serum of patients with autoimmune diseases in vitro.
Specific intravenous immunoglobulin for Crimean-Congo haemorrhagic fever
Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.
- S. Kaveri, T. Vassilev, M. Kazatchkine
- Biology, MedicineJournal of Clinical Investigation
- 1 February 1996
It is reported here that IVIg recognizes the B07.75-84 peptide, corresponding to a conserved region of the alpha I helix of the first domain of HLA-B7 01, which represents a nonpolymorphic determinant of Hla class I molecules.
The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites
A strikingly universal architecture of this repertoire with modular organization among different donor populations revealed an association between immunogenicity or tolerance and particular structural features of glycans, which reveals potential glycan antigen determinants relevant to vaccine design, diagnostic assays, and antibody-based therapies.
Optimization of casein-based semisynthetic medium for growing of toxigenic Corinebacterium diphtheriae in a fermenter.
- A. Tchorbanov, J. Dimitrov, T. Vassilev
- Biology, MedicineCanadian journal of microbiology
- 1 October 2004
It is established that the optimal pH for toxin production is 7.2 and under these conditions, diphtheria toxin with higher purity and yield compared with the batches obtained using the meat-based medium of Pope-Lingood was produced.
Antibodies to the CD5 molecule in normal human immunoglobulins for therapeutic use (intravenous immunoglobulins, IVIg)
- T. Vassilev, C. Gélin, S. Kaveri, M. Zilber, L. Boumsell, M. Kazatchkine
- Biology, MedicineClinical and experimental immunology
- 1 June 1993
Thai IVIg contain antibodies directed againsl CD5, a cell surface molecule of T cells which is also a marker of the autoantibody‐producing CD20+(‘B‐r) subset of B lymphocyies, which provide therapeutic immunoglobulin preparations with the potential of modulating Tcell functions through CD5.
Antibody Polyreactivity in Health and Disease: Statu Variabilis
- J. Dimitrov, C. Planchais, L. Roumenina, T. Vassilev, S. Kaveri, S. Lacroix-Desmazes
- BiologyThe Journal of Immunology
- 1 August 2013
This review integrates and discusses different findings that reveal the indispensable role of Ag-binding polyreactivity in the immune system and describes the functional and molecular characteristics of polyreactive Abs and BCRs.
IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist
The authors promote a recently challenged concept that the sialylation of IgG Fc fragments is likely to be responsible for the therapeutic activity of IVIG, however, they fall short in their discussion of the experimental evidence that does not support this concept.
Natural Polyreactive IgA and IgM Autoantibodies in Human Colostrum
The authors hypothesize that the natural autoantibodies in colostrum and milk may contribute to the selection process of physiological repertoire during the early postnatal period in breast‐fed infants, which could explain the lower frequency of allergic, inflammatory and autoimmune diseases and lymphomas seen in their later life when compared with that observed in children who have been formula‐fed after birth.
The Autoreactivity of Therapeutic Intravenous Immunoglobulin (IVIg) Preparations Depends on the Fractionation Methods Used
- I. Djoumerska, A. Tchorbanov, A. Pashov, T. Vassilev
- Biology, MedicineScandinavian journal of immunology
- 1 April 2005
The treatment of IVIg at low pH resulted in increasing the inhibitory effect of the pooled IgG on PHA‐induced proliferation of human peripheral blood mononuclear cells and may have different immunomodulating activities when infused to autoimmune patients.