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The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites
TLDR
A strikingly universal architecture of this repertoire with modular organization among different donor populations revealed an association between immunogenicity or tolerance and particular structural features of glycans, which reveals potential glycan antigen determinants relevant to vaccine design, diagnostic assays, and antibody-based therapies. Expand
Pooled normal human polyspecific IgM contains neutralizing anti-idiotypes to IgG autoantibodies of autoimmune patients and protects from experimental autoimmune disease.
TLDR
It is shown that poolednormal human IgM (IVIgM) purified from plasma of more than 2,500 healthy donors and processed in a similar fashion to that of therapeutic preparations of pooled normal human IgG (IVG) suppresses activity of IgG autoantibodies purified from the serum of patients with autoimmune diseases in vitro. Expand
Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use.
TLDR
It is reported here that IVIg recognizes the B07.75-84 peptide, corresponding to a conserved region of the alpha I helix of the first domain of HLA-B7 01, which represents a nonpolymorphic determinant of Hla class I molecules. Expand
Optimization of casein-based semisynthetic medium for growing of toxigenic Corinebacterium diphtheriae in a fermenter.
TLDR
It is established that the optimal pH for toxin production is 7.2 and under these conditions, diphtheria toxin with higher purity and yield compared with the batches obtained using the meat-based medium of Pope-Lingood was produced. Expand
Antibodies to the CD5 molecule in normal human immunoglobulins for therapeutic use (intravenous immunoglobulins, IVIg)
TLDR
Thai IVIg contain antibodies directed againsl CD5, a cell surface molecule of T cells which is also a marker of the autoantibody‐producing CD20+(‘B‐r) subset of B lymphocyies, which provide therapeutic immunoglobulin preparations with the potential of modulating Tcell functions through CD5. Expand
The Autoreactivity of Therapeutic Intravenous Immunoglobulin (IVIg) Preparations Depends on the Fractionation Methods Used
TLDR
The treatment of IVIg at low pH resulted in increasing the inhibitory effect of the pooled IgG on PHA‐induced proliferation of human peripheral blood mononuclear cells and may have different immunomodulating activities when infused to autoimmune patients. Expand
IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist
TLDR
The authors promote a recently challenged concept that the sialylation of IgG Fc fragments is likely to be responsible for the therapeutic activity of IVIG, however, they fall short in their discussion of the experimental evidence that does not support this concept. Expand
Normal human immunoglobulin suppresses experimental myasthenia gravis in SCID mice
TLDR
Findings indicate that pooled normal IgM exerts an immunoregulatory role in experimental myasthenia gravis, and suggests that IgM may be considered as an alternative approach in the therapy of autommune diseases. Expand
An antibody-based construct carrying DNA-mimotope and targeting CR1(CD35) selectively suppresses human autoreactive B-lymphocytes.
TLDR
It is found that the DNA-like peptide chimera induced a dose-dependent decrease in the number of IgG anti-dsDNA antibody producing cells when PBMCs of lupus patients were cultured in its presence. Expand
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