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KNK 437

Known as: KNK-437, KNK437 
National Institutes of Health

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2 relations

Broader (2)

Benzhydryl CompoundsPyrrolidinones

Papers overview

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2013
2013
Resistin protects against 6‐hydroxydopamine‐induced cell death in dopaminergic‐like MES23.5 cells
Resistin is originally reported as an adipose tissue‐specific hormone and is thought to represent a link between obesity and… 
2012
2012
Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes
Alkannin is an active constituent from the root extract of Alkanna tinctoria of the Boraginaceae family and it may have utility… 
2011
2011
p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro.
2011
2011
Combining Curcumin (Diferuloylmethane) and Heat Shock Protein Inhibition for Neurofibromatosis 2 Treatment: Analysis of Response and Resistance Pathways
Neurofibromatosis type 2 (NF2) is a genetic condition characterized by inactivation of the NF2 tumor suppressor gene and the… 
2011
2011
KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia
Hyperthermia is known to serve as a powerful tool in the treatment of prostate cancer which is commonly diagnosed in men… 
2010
2010
Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.
2009
2009
Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of…
Highly Cited
2007
Highly Cited
2007
Examination of KNK437- and quercetin-mediated inhibition of heat shock-induced heat shock protein gene expression in Xenopus laevis cultured cells.
2006
2006
Oral Pretreatment with Ebselen Enhances Heat Shock Protein 72 Expression and Reduces Myocardial Infarct Size
Reactive oxygen species (ROS) enhance myocardial ischemia-reperfusion (I/R) injury. Ebselen, a seleno-organic glutathione… 
2006
2006
The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells
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