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KNK 437

Known as: KNK-437, KNK437 
National Institutes of Health

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2 relations

Broader (2)

Benzhydryl CompoundsPyrrolidinones

Papers overview

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2013
2013
Resistin protects against 6‐hydroxydopamine‐induced cell death in dopaminergic‐like MES23.5 cells
Resistin is originally reported as an adipose tissue‐specific hormone and is thought to represent a link between obesity and… 
2013
2013
Hyperbaric oxygen treatment prevents nitric oxide‐induced apoptosis in articular cartilage injury via enhancement of the expression of heat shock protein 70
Heat shock proteins (HSPs), inflammatory cytokines, nitric oxide (NO), and localized hypoxia‐induced apoptosis are thought to be… 
Highly Cited
2011
Highly Cited
2011
Acute heat treatment improves insulin-stimulated glucose uptake in aged skeletal muscle.
Aging is associated with insulin resistance and decreased insulin-stimulated glucose uptake into skeletal muscle. Although the… 
2010
2010
KNK437 Downregulates Heat Shock Protein 27 of Pancreatic Cancer Cells and Enhances the Cytotoxic Effect of Gemcitabine
Background: Our previous proteomic study demonstrated that expression of heat shock protein 27 (HSP27) is upregulated in… 
2010
2010
Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.
2010
2010
Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells
Previous studies have shown that inhibiting the activity of the proteasome leads to the accumulation of damaged or unfolded… 
2009
2009
Azithromycin Reduces Tumor Necrosis Factor-Alpha Production in Lipopolysaccharide-Stimulated THP-1 Monocytic Cells by Modification of Stress Response and p38 MAPK Pathway
Abstract Macrolide antibiotics are known to have a variety of immunomodulatory effects in addition to antimicrobial activity, but… 
Highly Cited
2007
Highly Cited
2007
Examination of KNK437- and quercetin-mediated inhibition of heat shock-induced heat shock protein gene expression in Xenopus laevis cultured cells.
2006
2006
Oral Pretreatment with Ebselen Enhances Heat Shock Protein 72 Expression and Reduces Myocardial Infarct Size
Reactive oxygen species (ROS) enhance myocardial ischemia-reperfusion (I/R) injury. Ebselen, a seleno-organic glutathione… 
Highly Cited
2001
Highly Cited
2001
The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo.
A newly synthesized reagent, KNK437, has been found specifically to inhibit the synthesis of heat shock proteins in vitro. In… 
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