Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes

  title={Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes},
  author={Yoko Yoshihisa and Mariame Ali Hassan and Yukihiro Furusawa and Yoshiaki Tabuchi and Takashi Kondo and Tadamichi Shimizu},
  booktitle={PloS one},
Alkannin is an active constituent from the root extract of Alkanna tinctoria of the Boraginaceae family and it may have utility as a heat shock protein 70 (HSP70) inducer in living organisms. Here, the effects of alkannin-induced HSP70 on ultraviolet (UV) B (40 mJ/cm(2))-induced apoptosis were investigated in human keratinocyte HaCaT cells. Pretreatment of cells with alkannin (1 µM) caused significant inhibition of UVB-induced apoptosis and caspase-3 cleavage. On the other hand, the addition of… CONTINUE READING
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