KNI-727
National Institutes of Health
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A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P(2)' moieties were synthesized…
Combination therapy, or highly active antiretroviral therapy (HAART) comprising at least three anti-HIV drugs, nucleoside…
We designed and synthesized a series of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727 (1), which is a sparingly…
Plasmepsin II is a key enzyme in the life cycle of the Plasmodium parasites responsible for malaria, a disease that afflicts more…