KNI-727

A series of HIV protease inhibitor based on the allophenylnorstatine structure with various P(2)' moieties were synthesized… Expand

Combination therapy, or highly active antiretroviral therapy (HAART) comprising at least three anti-HIV drugs, nucleoside… Expand

To improve the low water-solubility of HIV protease inhibitors, we synthesized water-soluble prodrugs of KNI-727, a potent small… Expand

We designed and synthesized a series of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727 (1), which is a sparingly… Expand

Plasmepsin II is a key enzyme in the life cycle of the Plasmodium parasites responsible for malaria, a disease that afflicts more… Expand

We designed and synthesized a series of highly water-soluble prodrugs of an HIV protease inhibitor, KNI-727 (1), containing… Expand