• Publications
  • Influence
Rejection properties of non-phenylic pesticides with nanofiltration membranes
Abstract Pesticides pollution in surface and ground water has reached a serious level of pollution and the development of pesticides removal technologies is an important subject for reducing the riskExpand
  • 196
  • 9
Effects of hydrophobicity and molecular size on rejection of aromatic pesticides with nanofiltration membranes
Abstract Membrane filtration is a promising technology to remove hazardous organic micro-pollutants, such as pesticides, dyes, and many other synthesized products. In our previous work weExpand
  • 244
  • 8
NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent
The diketopiperazine NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells. AlthoughExpand
  • 196
  • 5
The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design.
KNI-764 is a powerful HIV-1 protease inhibitor with a reported low susceptibility to the effects of protease mutations commonly associated with drug resistance. In this paper the bindingExpand
  • 138
  • 5
Compensating Enthalpic and Entropic Changes Hinder Binding Affinity Optimization
A common strategy to improve the potency of drug candidates is to introduce chemical functionalities, like hydrogen bond donors or acceptors, at positions where they are able to establish strongExpand
  • 156
  • 3
  • PDF
Overcoming Roadblocks in Lead Optimization: A Thermodynamic Perspective
One of the most important goals in the development of lead compounds is the optimization of their binding affinity towards the intended target, as binding affinity is directly related to potency.Expand
  • 108
  • 3
Thermodynamic dissection of the binding energetics of KNI‐272, a potent HIV‐1 protease inhibitor
KNI‐272 is a powerful HIV‐1 protease inhibitor with a reported inhibition constant in the picomolar range. In this paper, a complete experimental dissection of the thermodynamic forces that defineExpand
  • 85
  • 3
High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.
Drug development against viral or microbial targets is often compounded by the existence of naturally occurring polymorphisms or drug resistant mutations. In the case of Plasmodium falciparum, theExpand
  • 92
  • 3
“Click Peptide“: pH‐Triggered in Situ Production and Aggregation of Monomer Aβ1–42
Into neutral: We demonstrate the unique features of a pH click peptide based on an O‐acyl isopeptide method. Under acidic conditions, the click peptide remains in a monomeric form. Upon increase ofExpand
  • 49
  • 3
Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical
We designed and synthesized a series of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727 (1), which is a sparingly water-soluble drug with a water solubility of 5.5 microg/mL. TheseExpand
  • 33
  • 3