Skip to search form
Skip to main content
>
Semantic Scholar
Semantic Scholar's Logo
Search
Sign In
Create Free Account
You are currently offline. Some features of the site may not work correctly.
KMI-429
National Institutes of Health
Create Alert
Related topics
Related topics
1 relation
Broader (1)
Oligopeptides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P(2) position.
Y. Hamada
,
K. Suzuki
,
+7 authors
Y. Kiso
Bioorganic & medicinal chemistry letters
2014
Corpus ID: 206258725
We have previously reported potent substrate-based pentapeptidic BACE1 inhibitors possessing a hydroxymethylcarbonyl isostere as…
Expand
2012
2012
BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?
Y. Hamada
,
S. Ishiura
,
Y. Kiso
ACS medicinal chemistry letters
2012
Corpus ID: 12928571
Recently, we reported substrate-based pentapeptidic β-secretase (BACE1) inhibitors with a hydroxymethylcarbonyl isostere as a…
Expand
2008
2008
BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.
Y. Hamada
,
Hamdy M. Abdel-Rahman
,
+8 authors
Y. Kiso
Bioorganic & medicinal chemistry letters
2008
Corpus ID: 33789458
Recently, we reported potent BACE1 inhibitors KMI-429, -684, and -574 possessing a hydroxymethylcarbonyl isostere as a substrate…
Expand
2006
2006
The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
M. Asai
,
C. Hattori
,
+8 authors
S. Ishiura
Journal of neurochemistry
2006
Corpus ID: 23016335
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid plaques and neurofibrillary…
Expand
Highly Cited
2006
Highly Cited
2006
Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.
T. Kimura
,
Y. Hamada
,
+9 authors
Y. Kiso
Bioorganic & medicinal chemistry letters
2006
Corpus ID: 36772790
Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-420 and KMI-429 in which we replaced the Glu…
Expand
2006
2006
beta-Secretase inhibitors: modification at the P4 position and improvement of inhibitory activity in cultured cells.
Y. Hamada
,
Naoto Igawa
,
+10 authors
Y. Kiso
Bioorganic & medicinal chemistry letters
2006
Corpus ID: 35029627
Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced…
Expand
2006
2006
Binding Energetics of KMI-420 and KMI-429
남연민
,
최호섭
,
허준
,
저원
,
조원호
2006
Corpus ID: 101380381
Highly Cited
2005
Highly Cited
2005
Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability.
T. Kimura
,
D. Shuto
,
+7 authors
Y. Kiso
Bioorganic & medicinal chemistry letters
2005
Corpus ID: 29009935
Recently, we reported potent and small-sized BACE1 inhibitors KMI-358 and KMI-370 in which the Glu residue is replaced by a beta…
Expand
2005
2005
Design and Synthesis of Highly Active β-Secretase (BACE1) inhibitors, KMI-420 and KMI-429, with Enhanced Chemical Stability
Y. Hamada
,
T. Kimura
,
+7 authors
Y. Kiso
2005
Corpus ID: 86050406
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE