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KLRF1 gene

Known as: KLRF1, NKp80, CLEC5C 
National Institutes of Health

Papers overview

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2015
2015
HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity
NK cells detect tumors through activating surface receptors, which bind self-antigens that are frequently expressed upon… 
2013
2013
Membrane‐bound interleukin‐21 and CD137 ligand induce functional human natural killer cells from peripheral blood mononuclear cells through STAT‐3 activation
Natural killer (NK) cell adoptive transfer is a promising approach for cancer immunotherapy; however, its development has been… 
2013
2013
Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.
NKp80 is a C-type lectin-like receptor broadly expressed on human natural killer (NK) cells, triggering cytotoxicity via an… 
2012
2012
Effect of Recombinant Cytokines on the Expression of Natural Killer Cell Receptors from Patients with TB or/and HIV Infection
Background NK cells express several specialized receptors through which they recognize and discriminate virally-infected/tumor… 
2011
2011
Cutting Edge: NKp80 Uses an Atypical Hemi-ITAM To Trigger NK Cytotoxicity
The human NK cell receptor NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand AICL. However, the… 
2010
2010
The Association of MHC Class I Proteins with the 2B4 Receptor Inhibits Self-Killing of Human NK Cells
The killing activity of NK cells is carried out by several activating NK receptors, which includes NKp46, NKp44, NKp30, NKp80… 
Highly Cited
2009
Highly Cited
2009
NKp80 defines and stimulates a reactive subset of CD8 T cells.
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK… 
Highly Cited
2006
Highly Cited
2006
Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction
Receptors encoded by the natural killer (NK) cell gene complex (such as NKG2D) govern the reactivity of NK cells. However, the… 
Highly Cited
2005
Highly Cited
2005
Identification of NKG2A and NKp80 as specific natural killer cell markers in rhesus and pigtailed monkeys.
Investigations of natural killer (NK) cells in simian models of disease have been hampered by a lack of appropriate phenotypic… 
2005
2005
Molecular and Functional Characterization of NKG2D, NKp80, and NKG2C Triggering NK Cell Receptors in Rhesus and Cynomolgus Macaques: Monitoring of NK Cell Function during Simian HIV Infection1
An involvement of innate immunity and of NK cells during the priming of adaptive immune responses has been recently suggested in… 
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