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KLF1 gene

Known as: EKLF, Kruppel-like factor 1 (erythroid), KRUPPEL-LIKE FACTOR 1 
This gene is involved in both transcriptional regulation and erythrocyte differentiation.
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Until recently our approach to analyzing human genetic diseases has been to accurately phenotype patients and sequence the genes… Expand
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Highly Cited
2013
Highly Cited
2013
The fetal-to-adult hemoglobin switch and silencing of fetal hemoglobin (HbF) have been areas of long-standing interest among… Expand
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Highly Cited
2011
Highly Cited
2011
Increased hemoglobin A(2) (HbA(2); ie, levels > 3.9%) is the most important feature of β-thalassemia carriers. However, it is not… Expand
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Highly Cited
2010
Highly Cited
2010
We show that knockdown of KLF1 in human and mouse adult erythroid progenitors markedly reduces BCL11A levels and increases human… Expand
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Highly Cited
2010
Highly Cited
2010
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults… Expand
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Highly Cited
2010
Highly Cited
2010
The congenital dyserythropoietic anemias (CDAs) are inherited red blood cell disorders whose hallmarks are ineffective… Expand
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Highly Cited
2010
Highly Cited
2010
KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the… Expand
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Highly Cited
2010
Highly Cited
2010
The c-myb transcription factor is highly expressed in immature hematopoietic cells and down-regulated during differentiation. To… Expand
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Highly Cited
2008
Highly Cited
2008
Comparison of normal erythroblasts and erythroblasts from persons with the rare In(Lu) type of Lu(a-b-) blood group phenotype… Expand
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Highly Cited
2003
Highly Cited
2003
ABSTRACT FLI-1 is an ETS family transcription factor which is overexpressed in Friend erythroleukemia and contributes to the… Expand
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