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KIT wt Allele

Known as: SCFR, Stem Cell Factor Receptor Gene, CD117 
Human KIT wild-type allele is located within 4q11-q12 and is approximately 83 kb in length. This allele, which encodes mast/stem cell growth factor… 
National Institutes of Health

Related topics

Related topics

18 relations
4q11-q12C-KIT GeneGastrointestinal Stromal TumorsGerm cell tumor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway.
Highly Cited
2001
Highly Cited
2001
A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis.
Highly Cited
2000
Highly Cited
2000
Effects of loss-of-function and gain-of-function mutations of c-kit on the gastrointestinal tract.
Protooncogene c-kit encodes a receptor tyrosine kinase, KIT. Interstitial cells of Cajal (ICCs) that are important for the… 
Highly Cited
1997
Highly Cited
1997
Localization and expression of the c-kit receptor protein in human and rodent testis and sperm.
Highly Cited
1996
Highly Cited
1996
Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells.
Previous studies have suggested that Steel factor (SF) can influence the behavior of many types of hematopoietic progenitor cells… 
Highly Cited
1995
Highly Cited
1995
c‐kit point mutation of extracellular domain in patients with myeloproliferative disorders
Summary. c‐kit is a tyrosine kinase receptor whose ligand is stem cell factor (SCF). Gene alteration of the c‐kit extracellular… 
Highly Cited
1994
Highly Cited
1994
Expression of the c-kit receptor in human lymphomas is restricted to Hodgkin's disease and CD30+ anaplastic large cell lymphomas.
The product of the proto-oncogene c-kit is a transmembrane receptor protein that plays an important role in the regulation of… 
Highly Cited
1994
Highly Cited
1994
AML: immunophenotypic heterogeneity and prognostic significance of c-kit expression.
Antigenic profiles in AML that have generally accepted prognostic significance, and allow treatment stratification, have not yet… 
Highly Cited
1994
Highly Cited
1994
Expression of the c-kit proto-oncogene in myeloproliferative disorders and myelodysplastic syndromes.
The c-kit proto-oncogene is the receptor gene for the stem cell growth factor. Little is known about the distribution and role of… 
Highly Cited
1993
Highly Cited
1993
Expression of adhesion molecules and c-kit on CD34+ hematopoietic progenitor cells: comparison of cytokine-mobilized blood stem cells with normal bone marrow and peripheral blood.
We assessed the expression of the adhesion molecules leukocyte function antigen-1 (LFA-1, CD11a), intercellular adhesion molecule… 
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