Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
- S. Hirota, K. Isozaki, Y. Kitamura
- Biology, ChemistryScience
- 23 January 1998
Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development.
Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
- T. Komori, H. Yagi, T. Kishimoto
- BiologyCell
- 30 May 1997
Lethal effect of the anti-Fas antibody in mice
- J. Ogasawara, R. Watanabe‐Fukunaga, S. Nagata
- BiologyNature
- 26 August 1993
The findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases.
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
- T. Nagasawa, S. Hirota, T. Kishimoto
- Biology, MedicineNature
- 15 August 1996
It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumors.
- S. Hirota, A. Ohashi, Y. Kitamura
- Biology, MedicineGastroenterology
- 1 September 2003
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
- K. Tachibana, S. Hirota, T. Nagasawa
- Biology, MedicineNature
- 11 June 1998
PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization, and it is reported that CX CR4 is expressed in developing vascular endothelial cells, and that mice lacking CxCR4 or PBSF/ sdf-1 have defective formation of the large vessels supplying the gastrointestinal tract.
Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation.
- Y. Kitamura, S. Go, K. Hatanaka
- Biology, MedicineBlood
- 1 August 1978
The results show that the W/Wv mouse is a useful tool for the investigations concerning the physiologic roles and the origin of mast cells.
Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors.
- M. Taniguchi, T. Nishida, Y. Kitamura
- BiologyCancer Research
- 1 September 1999
The results suggest that GISTs may be divided into mutation-positive and -negative subtypes and that mutation of the c-kit gene may be a good prognostic marker of Gists.
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
- T. Nishida, S. Hirota, Y. Kitamura
- Medicine, BiologyNature Genetics
- 1 August 1998
nature genetics volume 19 august 1998 323 Gastrointestinal stromal tumour (GIST) is the most common mesenchymal tumour of the human gastrointestinal tract. Most GISTs are solitary, and…
Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation*
- H. Enomoto, M. Enomoto-Iwamoto, T. Komori
- Biology, MedicineJournal of Biological Chemistry
- 24 March 2000
Results indicate that Cbfa1 is an important regulatory factor in chondrocyte maturation and treatment with antisense oligonucleotides reduces type X collagen expression in ATDC5 cells.
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