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KIR2DL3 gene

Known as: NKAT2B, NKAT2, CD158B2 
This gene is involved in the inhibition of natural killer cell-mediated cell lysis.
National Institutes of Health

Related topics

Related topics

5 relations
Immune responseKIR2DL3 protein, humanKIR2DL3 wt AlleleLigand Binding
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Papers overview

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2014
2014
KIR2DL3⁺NKG2A⁻ natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs.
BACKGROUND & AIMS Despite continuous high-risk behavior, a subgroup among people who inject drugs (PWID) remains seronegative for… Expand
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Highly Cited
2013
Highly Cited
2013
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their… Expand
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2013
2013
Amplified NKG2C+ NK cells in cytomegalovirus (CMV) infection preferentially express killer cell Ig-like receptor 2DL: functional impact in controlling CMV-infected dendritic cells.
CMV infection represents a major complication in hematopoietic stem cell transplantation, which compromises graft outcome… Expand
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Highly Cited
2009
Highly Cited
2009
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.
Natural killer (NK) cells contribute to immunity and reproduction. Guiding these functions, and NK cell education, are killer… Expand
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Highly Cited
2008
Highly Cited
2008
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.
Interactions between HLA-C ligands and inhibitory killer cell Ig-like receptors (KIR) control the development and response of… Expand
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Highly Cited
2004
Highly Cited
2004
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for… Expand
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Highly Cited
2004
Highly Cited
2004
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture.
Efficient replication of hepatitis C virus (HCV) subgenomic RNA in cell culture requires the introduction of adaptive mutations… Expand
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Highly Cited
2001
Highly Cited
2001
Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells
Sophie Ugolini et al. Nature Immunology 2, 430–435 (2001). In the May issue of Nature Immunology some references and text were… Expand
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Highly Cited
1999
Highly Cited
1999
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.
Human natural killer cells and a subset of T cells express a repertoire of killer cell immunoglobulin receptors (KIRs) that… Expand
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Highly Cited
1998
Highly Cited
1998
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.
Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. To… Expand
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