FAQ

KIR2DL3 gene

Known as: NKAT2B, NKAT2, CD158B2 
This gene is involved in the inhibition of natural killer cell-mediated cell lysis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0102019982018

Related topics

Related topics

5 relations
Immune responseKIR2DL3 protein, humanKIR2DL3 wt AlleleLigand Binding
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
KIR2DL3 gene
Immune response
Receptor Signaling
Ligand Binding
KIR2DL3 wt Allele
KIR2DL3 protein, human

Papers overview

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2012
2012
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
Through recognition of HLA class I, killer cell Ig-like receptors (KIR) modulate NK cell functions in human immunity and… (More)
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Highly Cited
2010
Highly Cited
2010
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.
Expression of inhibitory killer cell immunoglobulin-like receptors (KIRs) specific for self-major histocompatibility complex (MHC… (More)
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2009
2009
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.
Natural killer (NK) cells contribute to immunity and reproduction. Guiding these functions, and NK cell education, are killer… (More)
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2009
2009
Susceptibility to Crohn’s disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand
In the present study, we investigated the relationship between the KIR loci and the genes encoding their HLA ligands and genetic… (More)
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Highly Cited
2008
Highly Cited
2008
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.
Interactions between HLA-C ligands and inhibitory killer cell Ig-like receptors (KIR) control the development and response of… (More)
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Highly Cited
2004
Highly Cited
2004
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for… (More)
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1999
1999
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.
Human natural killer cells and a subset of T cells express a repertoire of killer cell immunoglobulin receptors (KIRs) that… (More)
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1999
1999
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.
BACKGROUND T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify… (More)
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1999
1999
Modulation of T-cell functions in KIR2DL3 (CD158b) transgenic mice.
In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with… (More)
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Highly Cited
1998
Highly Cited
1998
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.
Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. To… (More)
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