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KIR2DL3 gene
Known as:
NKAT2B
, NKAT2
, CD158B2
Â
(More)
This gene is involved in the inhibition of natural killer cell-mediated cell lysis.
National Institutes of Health
Topic mentions per year
Topic mentions per year
1998-2018
0
10
20
1998
2018
Related topics
Related topics
5 relations
Immune response
KIR2DL3 protein, human
KIR2DL3 wt Allele
Ligand Binding
(More)
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
KIR2DL3 gene
Immune response
Receptor Signaling
Ligand Binding
KIR2DL3 wt Allele
KIR2DL3 protein, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.
Hugo G Hilton
,
Luca Vago
,
+7 authors
Peter Parham
Journal of immunology
2012
Through recognition of HLA class I, killer cell Ig-like receptors (KIR) modulate NK cell functions in human immunity and…Â
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Highly Cited
2010
Highly Cited
2010
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.
Cyril Fauriat
,
Martin A Ivarsson
,
H G Ljunggren
,
K A Malmberg
,
Jakob Michaëlsson
Blood
2010
Expression of inhibitory killer cell immunoglobulin-like receptors (KIRs) specific for self-major histocompatibility complex (MHC…Â
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2009
2009
Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.
Ketevan Gendzekhadze
,
Paul J Norman
,
+4 authors
Peter Parham
Proceedings of the National Academy of Sciences…
2009
Natural killer (NK) cells contribute to immunity and reproduction. Guiding these functions, and NK cell education, are killer…Â
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2009
2009
Susceptibility to Crohn’s disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand
Jill A. Hollenbach
,
Martha B. Ladner
,
+7 authors
Elizabeth A. Trachtenberg
Immunogenetics
2009
In the present study, we investigated the relationship between the KIR loci and the genes encoding their HLA ligands and genetic…Â
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Highly Cited
2008
Highly Cited
2008
Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.
Achim K. Moesta
,
Paul J Norman
,
Makoto Yawata
,
Nobuyo Yawata
,
Michael Gleimer
,
Peter Parham
Journal of immunology
2008
Interactions between HLA-C ligands and inhibitory killer cell Ig-like receptors (KIR) control the development and response of…Â
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Highly Cited
2004
Highly Cited
2004
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection.
Salim I Khakoo
,
Chloe L. Thio
,
+15 authors
Mary Carrington
Science
2004
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for…Â
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1999
1999
Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.
Kazusuke Maenaka
,
Takuo Juji
,
+11 authors
Pier van der Merwe
The Journal of biological chemistry
1999
Human natural killer cells and a subset of T cells express a repertoire of killer cell immunoglobulin receptors (KIRs) that…Â
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1999
1999
Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I.
Kazusuke Maenaka
,
Takuo Juji
,
David I Stuart
,
E. Y. Jones
Structure
1999
BACKGROUND T cells and natural killer (NK) cells perform complementary roles in the cellular immune system. T cells identify…Â
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1999
1999
Modulation of T-cell functions in KIR2DL3 (CD158b) transgenic mice.
Anna Cambiaggi
,
Sylvie Darche
,
Sophie Guia
,
P. Kourilsky
,
J P Abastado
,
Emmanuelle Vivier
Blood
1999
In humans, a minor subset of T cells express killer cell Ig-like receptors (KIRs) at their surface. In vitro data obtained with…Â
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Highly Cited
1998
Highly Cited
1998
Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.
Christian Winter
,
Jenny E. Gumperz
,
Paul Parham
,
E. O. Long
,
Nicolai R. Wagtmann
Journal of immunology
1998
Cytotoxicity of human NK cells is under negative control of killer cell Ig-like receptors (KIR) specific for HLA class I. To…Â
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