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KGP94

National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

ThiosemicarbazonesThiourea
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 186: Small-molecule inhibition of cathepsins L and K as potential therapeutics for macrophage-driven breast cancer
Tumor-associated macrophages secrete many factors including proteases and growth factors, which ultimately promote the metastatic… 
2017
2017
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
2017
2017
Creating a High-Resolution Descending Motor Template Using Human Connectome Project Data
Background: Bone metastasis is common in different cancers, and increases morbidity and mortality. The goals of this study were… 
2016
2016
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
A significant proportion of breast cancer patients harbor clinically undetectable micrometastases at the time of diagnosis. If… 
2015
2015
Abstract 4498: Assessing the effects of the small molecule cathepsin L inhibitor, KGP94: combination with radiotherapy and evaluation of antimetastatic potential in vivo
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Introduction: KGP94, a small molecule cathepsin… 
2014
2014
Abstract 4030: In-vivo evaluation of the anti-metastatic efficacy of small molecule Cathepsin L inhibitor KGP94 in a prostate cancer model
It is estimated that ∼85% of patients with advanced prostate cancer develop skeletal metastases; an occurrence that results in a… 
2014
2014
Abstract 1816: Assessment of anti-tumor activity of the cathepsin L inhibitor, KGP94
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Purpose: The cysteine cathepsin proteases are known to… 
2013
2013
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells
Metastasis remains the major cause of therapeutic failure, poor prognosis and high mortality in breast and prostate cancer… 
2013
2013
Abstract A33: Small molecule cathepsin L inhibitor KGP94 suppresses hypoxia and acidosis potentiated metastatic capacity of prostate and breast cancer cells
Tumor metastasis is the primary cause of treatment failure and high mortality rates in prostate and breast cancer patients. The… 
2011
2011
Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
The discovery of new chemotherapeutic strategies for inhibiting the growth and spread of cancer represents an important goal in… 
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