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KDM6B wt Allele

Known as: Jumonji D3, Jumonji Domain Containing 3, Histone Lysine Demethylase Gene, KIAA0346 
Human KDM6B wild-type allele is located in the vicinity of 17p13.1 and is approximately 15 kb in length. This allele, which encodes lysine-specific… 
National Institutes of Health

Related topics

Related topics

8 relations
17p13.1Cell Differentiation processDevelopmental processHomo sapiens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
JMJD3 in the regulation of human diseases
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent… 
Highly Cited
2017
Highly Cited
2017
The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis
Objectives Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations… 
Highly Cited
2016
Highly Cited
2016
Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell-Like Behaviors in Hepatocellular Carcinoma.
The Jumonji domain-containing chromatin remodeling factor JMJD3 has important roles in development and cancer. Here, we report a… 
Highly Cited
2016
Highly Cited
2016
Histone H3K27 Demethylase JMJD3 in Cooperation with NF-κB Regulates Keratinocyte Wound Healing.
Review
2014
Review
2014
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process
Histone methylation is involved in the epigenetic control of immune responses and cellular senescence. Jumonji domain-containing… 
Highly Cited
2012
Highly Cited
2012
Expression and significance of histone H3K27 demethylases in renal cell carcinoma
BackgroundThe histone H3K27 demethylases UTX and JMJD3 are important regulatory factors that modulate gene expression by altering… 
Highly Cited
2012
Highly Cited
2012
Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization
Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases… 
2012
2012
Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes
The role of epigenetic regulation in inflammatory diseases such as periodontitis is poorly known. The aim of this study was to… 
Highly Cited
2011
Highly Cited
2011
H3K27 demethylation by JMJD3 at a poised enhancer of anti‐apoptotic gene BCL2 determines ERα ligand dependency
Chromatin represents a repressive barrier to the process of ligand‐dependent transcriptional activity of nuclear receptors. Here… 
Highly Cited
2011
Highly Cited
2011
p53 Interaction with JMJD3 Results in Its Nuclear Distribution during Mouse Neural Stem Cell Differentiation
Conserved elements of apoptosis are also integral components of cellular differentiation. In this regard, p53 is involved in… 
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