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Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system.
Excessive secretion of glucagon is a major contributor to the development of diabetic hyperglycemia. Secretion of glucagon is regulated by various nutrients, with glucose being a primary determinantExpand
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Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.
Ubiquitin is a key regulatory molecule in diverse cellular events. How cells determine the outcome of ubiquitylation remains unclear; however, a likely determinant is the specificity of ubiquitinExpand
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DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
The Rad23 family of proteins, including the human homologs hHR23a and hHR23b, stimulates nucleotide excision repair and has been shown to provide a novel link between proteasome-mediated proteinExpand
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Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2Expand
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Structural basis for receptor specificity of influenza B virus hemagglutinin
Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusivelyExpand
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Crystal Structure of Unliganded Influenza B Virus Hemagglutinin
ABSTRACT Here we report the crystal structure of hemagglutinin (HA) from influenza B/Hong Kong/8/73 (B/HK) virus determined to 2.8 Å. At a sequence identity of ∼25% to influenza A virus HAs, B/HK HAExpand
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Ubiquitin recognition by the DNA repair protein hHR23a.
Ubiquitin is a prominent regulatory protein in numerous biological processes, including targeted protein degradation, endocytic sorting, transcriptional control, intranuclear localization, andExpand
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Loss of conserved Gsdma3 self-regulation causes autophagy and cell death.
Gasdermin A3 (Gsdma3) was originally identified in association with hair-loss phenotype in mouse mutants. Our previous study found that AE mutant mice, with a Y344H substitution at the C-terminalExpand
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GLP-1(28-36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro.
Recent studies have demonstrated that the COOH-terminal fragment of the incretin hormone glucagon-like peptide-1 (GLP-1), a nonapeptide GLP-1(28-36)amide, attenuates diabetes and hepatic steatosis inExpand
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The role of insulin signaling in the development of β-cell dysfunction and diabetes
The peptide hormone insulin not only regulates metabolic pathways, but also proliferative signaling pathways. Insulin regulates cell proliferation, protein synthesis and gene expression in most, ifExpand
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