Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system.
- E. Xu, M. Kumar, +10 authors Qinghua Wang
- Biology, Medicine
- Cell metabolism
- 2006
Excessive secretion of glucagon is a major contributor to the development of diabetic hyperglycemia. Secretion of glucagon is regulated by various nutrients, with glucose being a primary determinant… Expand
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition.
- Qinghua Wang, Patrick Young, K. Walters
- Biology, Medicine
- Journal of molecular biology
- 6 May 2005
Ubiquitin is a key regulatory molecule in diverse cellular events. How cells determine the outcome of ubiquitylation remains unclear; however, a likely determinant is the specificity of ubiquitin… Expand
DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
- K. Walters, Patrycja J. Lech, A. M. Goh, Qinghua Wang, P. Howley
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 13 October 2003
The Rad23 family of proteins, including the human homologs hHR23a and hHR23b, stimulates nucleotide excision repair and has been shown to provide a novel link between proteasome-mediated protein… Expand
Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement
- Xiaorui Chen, Qinghua Wang, F. Ni, J. Ma
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 3 June 2010
Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage sensors and one pore domain. Because of high-level structural flexibility, the first mammalian Kv structure, Kv1.2… Expand
Structural basis for receptor specificity of influenza B virus hemagglutinin
- Qinghua Wang, X. Tian, Xiaorui Chen, J. Ma
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 23 October 2007
Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively… Expand
Crystal Structure of Unliganded Influenza B Virus Hemagglutinin
- Qinghua Wang, F. Cheng, Mingyang Lu, X. Tian, J. Ma
- Biology, Medicine
- Journal of Virology
- 9 January 2008
ABSTRACT Here we report the crystal structure of hemagglutinin (HA) from influenza B/Hong Kong/8/73 (B/HK) virus determined to 2.8 Å. At a sequence identity of ∼25% to influenza A virus HAs, B/HK HA… Expand
Ubiquitin recognition by the DNA repair protein hHR23a.
- Qinghua Wang, A. M. Goh, P. Howley, K. Walters
- Biology, Medicine
- Biochemistry
- 29 October 2003
Ubiquitin is a prominent regulatory protein in numerous biological processes, including targeted protein degradation, endocytic sorting, transcriptional control, intranuclear localization, and… Expand
Loss of conserved Gsdma3 self-regulation causes autophagy and cell death.
Gasdermin A3 (Gsdma3) was originally identified in association with hair-loss phenotype in mouse mutants. Our previous study found that AE mutant mice, with a Y344H substitution at the C-terminal… Expand
GLP-1(28-36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro.
- Weijuan Shao, Z. Wang, +6 authors T. Jin
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 15 June 2013
Recent studies have demonstrated that the COOH-terminal fragment of the incretin hormone glucagon-like peptide-1 (GLP-1), a nonapeptide GLP-1(28-36)amide, attenuates diabetes and hepatic steatosis in… Expand
The role of insulin signaling in the development of β-cell dysfunction and diabetes
- Qinghua Wang, T. Jin
- Medicine
- Islets
- 1 September 2009
The peptide hormone insulin not only regulates metabolic pathways, but also proliferative signaling pathways. Insulin regulates cell proliferation, protein synthesis and gene expression in most, if… Expand