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KCNH2 gene

Known as: POTASSIUM CHANNEL, VOLTAGE-GATED, SUBFAMILY H, MEMBER 2, Kv11.1, ETHER-A-GO-GO-RELATED GENE, HUMAN 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
The hERG cavity can trap very bulky compounds, without perturbing normal gate closure. 
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Highly Cited
2011
Highly Cited
2011
Aims The level of inhibition of the human Ether-à-go-go-related gene (hERG) channel is one of the earliest preclinical markers… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Levomethadyl acetate, methadone hydrochloride, and buprenorphine hydrochloride are equally effective treatments for… Expand
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Review
2006
Review
2006
hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause… Expand
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Highly Cited
2006
Highly Cited
2006
We created a homology model of the homo-tetrameric pore domain of HERG using the crystal structure of the bacterial potassium… Expand
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Review
2003
Review
2003
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Long-QT Syndrome (LQTS) is a cardiovascular disorder characterized by prolongation of the QT interval on ECG and… Expand
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Highly Cited
1999
Highly Cited
1999
A novel potassium channel gene has been cloned, characterized, and associated with cardiac arrhythmia. The gene encodes MinK… Expand
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Highly Cited
1995
Highly Cited
1995
Mutations in HERG cause an inherited cardiac arrhythmia, long QT syndrome (LQT). To define the function of HERG, we expressed the… Expand
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Highly Cited
1995
Highly Cited
1995
To identify genes involved in cardiac arrhythmia, we investigated patients with long QT syndrome (LQT), an inherited disorder… Expand
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