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Juvenile Pilocytic Astrocytoma

Known as: Pilocytic Astrocytoma, Juvenile, Astrocytoma, Juvenile Pilocytic, Juvenile Pilocytic Astrocytomas 
A slow-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord. Juvenile pilocytic… Expand
National Institutes of Health

Related topics

Related topics

15 relations
Anaplastic astrocytomaAstrocytesCentral Nervous SystemHeadache
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Broader (1)

Astrocytoma

Papers overview

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Highly Cited
2015
Highly Cited
2015
Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities
IDH wild type (IDHwt) anaplastic astrocytomas WHO grade III (AA III) are associated with poor outcome. To address the… Expand
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Highly Cited
2013
Highly Cited
2013
Epithelioid GBMs show a high percentage of BRAF V600E mutation.
BRAF V600E mutation has been identified in up to 2/3 of pleomorphic xanthoastrocytomas (PXAs), World Health Organization grade II… Expand
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Highly Cited
2011
Highly Cited
2011
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine… Expand
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Highly Cited
2009
Highly Cited
2009
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
Pilocytic astrocytomas (PAs), WHO malignancy grade I, are the most frequently occurring central nervous system tumour in 5- to 19… Expand
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Highly Cited
2009
Highly Cited
2009
Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
Background:Juvenile pilocytic astrocytomas (JPA), a subgroup of low-grade astrocytomas (LGA), are common, heterogeneous and… Expand
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Highly Cited
2009
Highly Cited
2009
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.
We report genetic aberrations that activate the ERK/MAP kinase pathway in 100% of posterior fossa pilocytic astrocytomas, with a… Expand
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Highly Cited
2009
Highly Cited
2009
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma
Separation of pilocytic astrocytoma from diffuse astrocytomas frequently poses problems mostly related to small sample size… Expand
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Review
2009
Review
2009
Epidemiology of brain tumors.
Gliomas account for more than 70% of all brain tumors, and of these, glioblastoma is the most frequent and malignant histologic… Expand
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Highly Cited
2008
Highly Cited
2008
Analysis of the IDH1 codon 132 mutation in brain tumors
A recent study reported on mutations in the active site of the isocitrate dehydrogenase (IDH1) gene in 12% of glioblastomas. All… Expand
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Highly Cited
1994
Highly Cited
1994
High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas.
We analysed 31 non-glioblastoma astrocytomas for alterations in p53 protein expression and for mutations in the p53 gene… Expand
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