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JTP 4819

Known as: JTP-4819 
National Institutes of Health

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Broader (1)

Pyrrolidines

Papers overview

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2014
2014
Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex
Highly Cited
2002
Highly Cited
2002
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.
1999
1999
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis
Review
1998
Review
1998
A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease
Formation of beta-amyloid and neurofibrillary tangles in the brain due to genetic or other factors is the most frequent cause of… 
1997
1997
Pharmacokinetics and safety of JTP-4819, a novel specific orally active prolyl endopeptidase inhibitor, in healthy male volunteers.
AIMS To investigate the pharmacokinetics and safety profile of JTP-4819, (-)-(2S)-1-benzylaminocarbonyl-[(2S)-2… 
Review
1997
Review
1997
A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease
Highly Cited
1995
Highly Cited
1995
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP‐4819, on Prolyl Endopeptidase Activity and Substance P‐ and Arginine‐Vasopressin‐Like Immunoreactivity in the Brains of Aged Rats
Abstract: The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)‐2‐[[(S)‐2‐(hydroxyacetyl)‐1‐pyrrolidinyl]carbonyl]‐N… 
1995
1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats.
We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl… 
1995
1995
老年痴呆症治療薬を目指す新規 prolyl endopeptidase 阻害薬, JTP-4819 の生化学的性質及び薬理活性
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