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JTP 4819

Known as: JTP-4819 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Pyrrolidines

Papers overview

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2011
2011
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.
Prolyl oligopeptidase (PREP) inhibitors are potential drug candidates for the treatment of neurological disorders, but little is… 
2008
2008
Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging
Highly Cited
2004
Highly Cited
2004
Purification, identification and characterisation of seprase from bovine serum.
2002
2002
4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.
Review
1998
Review
1998
A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease
Formation of beta-amyloid and neurofibrillary tangles in the brain due to genetic or other factors is the most frequent cause of… 
Highly Cited
1997
Highly Cited
1997
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats
1996
1996
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)-l-pyrrolidinyl] carbonyl]-N… 
Highly Cited
1995
Highly Cited
1995
JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.
JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N- phenylmethyl)-1-pyrrolidinecarboxamide) is a potent (IC50: 0… 
Highly Cited
1995
Highly Cited
1995
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP‐4819, on Prolyl Endopeptidase Activity and Substance P‐ and Arginine‐Vasopressin‐Like Immunoreactivity in the Brains of Aged Rats
Abstract: The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)‐2‐[[(S)‐2‐(hydroxyacetyl)‐1‐pyrrolidinyl]carbonyl]‐N… 
1995
1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats.
We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl… 
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