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JTP 4819
Known as:
JTP-4819
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Pyrrolidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.
Aaro J Jalkanen
,
J. Hakkarainen
,
+5 authors
M. Forsberg
Basic & clinical pharmacology & toxicology
2011
Corpus ID: 12590633
Prolyl oligopeptidase (PREP) inhibitors are potential drug candidates for the treatment of neurological disorders, but little is…
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2004
2004
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain
K. Toide
,
T. Fujiwara
,
Y. Iwamoto
,
M. Shinoda
,
K. Okamiya
,
T. Kato
Naunyn-Schmiedeberg's Archives of Pharmacology
2004
Corpus ID: 24533138
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)-l-pyrrolidinyl] carbonyl]-N…
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2002
2002
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.
J. Venäläinen
,
R. Juvonen
,
+5 authors
P. Maennistoe
Biochemical pharmacology
2002
Corpus ID: 40454774
Prolyl oligopeptidase (POP) is a cytosolic serine protease that hydrolyses small peptides at the carboxyl end of the proline…
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1999
1999
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis
M. Shinoda
,
A. Miyazaki
,
K. Toide
Behavioural Brain Research
1999
Corpus ID: 19155645
We conducted behavioral and neurochemical studies of a novel prolyl endopeptidase inhibitor, (S)2-[[(S)-2-(hydroxyacetyl…
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1998
1998
Effect of a Prolyl Endopeptidase Inhibitor, JTP-4819, on Radial Maze Performance in Hippocampal-Lesioned Rats
A. Miyazaki
,
K. Toide
,
Y. Sasaki
,
Y. Ichitani
,
T. Iwasaki
Pharmacology Biochemistry and Behavior
1998
Corpus ID: 1244808
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-2[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N…
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Highly Cited
1997
Highly Cited
1997
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats
K. Toide
,
M. Shinoda
,
T. Fujiwara
,
Y. Iwamoto
Pharmacology Biochemistry and Behavior
1997
Corpus ID: 22273802
The effects of a novel prolyl endopeptidase inhibitor (PEP), (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N…
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1996
1996
Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.
M. Shinoda
,
A. Matsuo
,
K. Toide
European journal of pharmacology
1996
Corpus ID: 39216189
We studied behavioral and pharmacological effects of a novel prolyl endopeptidase inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)- 1…
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Highly Cited
1995
Highly Cited
1995
JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.
K. Toide
,
Y. Iwamoto
,
T. Fujiwara
,
H. Abe
The Journal of pharmacology and experimental…
1995
Corpus ID: 21504384
JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N- phenylmethyl)-1-pyrrolidinecarboxamide) is a potent (IC50: 0…
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Highly Cited
1995
Highly Cited
1995
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP‐4819, on Prolyl Endopeptidase Activity and Substance P‐ and Arginine‐Vasopressin‐Like Immunoreactivity in the Brains of Aged Rats
K. Toide
,
K. Okamiya
,
Y. Iwamoto
,
T. Kato
Journal of neurochemistry
1995
Corpus ID: 42015625
Abstract: The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)‐2‐[[(S)‐2‐(hydroxyacetyl)‐1‐pyrrolidinyl]carbonyl]‐N…
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1995
1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats.
M. Shinoda
,
K. Okamiya
,
K. Toide
Japanese journal of pharmacology
1995
Corpus ID: 36878002
We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl…
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