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JTP 4819

Known as: JTP-4819 
 
National Institutes of Health

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Broader (1)

Pyrrolidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.
Prolyl oligopeptidase (PREP) inhibitors are potential drug candidates for the treatment of neurological disorders, but little is… Expand
2004
2004
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)-l-pyrrolidinyl] carbonyl]-N… Expand
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2002
2002
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.
Prolyl oligopeptidase (POP) is a cytosolic serine protease that hydrolyses small peptides at the carboxyl end of the proline… Expand
1999
1999
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on spatial memory and on cholinergic and peptidergic neurons in rats with ibotenate-induced lesions of the nucleus basalis magnocellularis
We conducted behavioral and neurochemical studies of a novel prolyl endopeptidase inhibitor, (S)2-[[(S)-2-(hydroxyacetyl… Expand
1998
1998
Effect of a Prolyl Endopeptidase Inhibitor, JTP-4819, on Radial Maze Performance in Hippocampal-Lesioned Rats
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-2[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N… Expand
Highly Cited
1997
Highly Cited
1997
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats
The effects of a novel prolyl endopeptidase inhibitor (PEP), (S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N… Expand
1996
1996
Pharmacological studies of a novel prolyl endopeptidase inhibitor, JTP-4819, in rats with middle cerebral artery occlusion.
We studied behavioral and pharmacological effects of a novel prolyl endopeptidase inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)- 1… Expand
Highly Cited
1995
Highly Cited
1995
JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.
JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N- phenylmethyl)-1-pyrrolidinecarboxamide) is a potent (IC50: 0… Expand
Highly Cited
1995
Highly Cited
1995
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP‐4819, on Prolyl Endopeptidase Activity and Substance P‐ and Arginine‐Vasopressin‐Like Immunoreactivity in the Brains of Aged Rats
Abstract: The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)‐2‐[[(S)‐2‐(hydroxyacetyl)‐1‐pyrrolidinyl]carbonyl]‐N… Expand
1995
1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats.
We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl… Expand
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