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JTP 4819
Known as:
JTP-4819
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Pyrrolidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.
Aaro J. Jalkanen
,
J. Hakkarainen
,
+5 authors
M. Forsberg
Basic & Clinical Pharmacology & Toxicology
2011
Corpus ID: 12590633
Prolyl oligopeptidase (PREP) inhibitors are potential drug candidates for the treatment of neurological disorders, but little is…
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2008
2008
Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging
M. J. Moreno-Baylach
,
V. Felipo
,
P. Männistö
,
J. Garcia-horsman
Neuroscience
2008
Corpus ID: 40502251
Highly Cited
2004
Highly Cited
2004
Purification, identification and characterisation of seprase from bovine serum.
P. Collins
,
G. McMahon
,
P. O'Brien
,
B. O'connor
International Journal of Biochemistry and Cell…
2004
Corpus ID: 38926824
2002
2002
4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.
Erik A. A. Wallén
,
J. Christiaans
,
+5 authors
J. Gynther
Bioorganic & Medicinal Chemistry
2002
Corpus ID: 8845247
Review
1998
Review
1998
A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's Disease
K. Toide
,
M. Shinoda
,
A. Miyazaki
Reviews in the Neurosciences
1998
Corpus ID: 24450362
Formation of beta-amyloid and neurofibrillary tangles in the brain due to genetic or other factors is the most frequent cause of…
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Highly Cited
1997
Highly Cited
1997
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Spatial Memory and Central Cholinergic Neurons in Aged Rats
K. Toide
,
M. Shinoda
,
T. Fujiwara
,
Y. Iwamoto
Pharmacology, Biochemistry and Behavior
1997
Corpus ID: 22273802
1996
1996
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain
K. Toide
,
T. Fujiwara
,
Y. Iwamoto
,
M. Shinoda
,
K. Okamiya
,
T. Kato
Naunyn-Schmiedeberg's Archives of Pharmacology
1996
Corpus ID: 24533138
The effect of a novel prolyl endopeptidase (PEP) inhibitor, (S)-2-[[(S)-2-(hydroxyacetyl)-l-pyrrolidinyl] carbonyl]-N…
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Highly Cited
1995
Highly Cited
1995
JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.
K. Toide
,
Y. Iwamoto
,
T. Fujiwara
,
H. Abe
Journal of Pharmacology and Experimental…
1995
Corpus ID: 21504384
JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N- phenylmethyl)-1-pyrrolidinecarboxamide) is a potent (IC50: 0…
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Highly Cited
1995
Highly Cited
1995
Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP‐4819, on Prolyl Endopeptidase Activity and Substance P‐ and Arginine‐Vasopressin‐Like Immunoreactivity in the Brains of Aged Rats
K. Toide
,
K. Okamiya
,
Y. Iwamoto
,
Takeshi Kato
Journal of Neurochemistry
1995
Corpus ID: 42015625
Abstract: The effects of a novel prolyl endopeptidase (PEP) inhibitor, (S)‐2‐[[(S)‐2‐(hydroxyacetyl)‐1‐pyrrolidinyl]carbonyl]‐N…
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1995
1995
Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on thyrotropin-releasing hormone-like immunoreactivity in the cerebral cortex and hippocampus of aged rats.
M. Shinoda
,
K. Okamiya
,
K. Toide
Japanese Journal of Pharmacology
1995
Corpus ID: 36878002
We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl…
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