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JSM6427

 
National Institutes of Health

Papers overview

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2009
2009
OBJECTIVE To evaluate the pharmacologic activity and tolerability of JSM6427, a potent and first selective small-molecule… Expand
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2009
2009
PURPOSE The aim of this study was to determine the expression and localization of integrin alpha5beta1 in human retinal pigment… Expand
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2009
2009
Methods: JSM6427 selectivity for 5 1 was evaluated by in vitro binding assays while the ability of JSM6427 to inhibit CNV was… Expand
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Review
2009
Review
2009
As researchers and clinicians are beginning to understand that wet age-related macular degeneration (AMD) is more than simply a… Expand
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2008
2008
Integrins are heterodimeric transmembrane proteins, which mediate cell-cell and cell-extracellular matrix (ECM) interaction. We… Expand
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2008
2008
JSM6427 is a highly potent and specific small molecule alpha(5)beta(1) integrin antagonist. JSM6427 blockade of alpha(5)beta(1… Expand
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2007
2007
PURPOSE Integrin alpha5beta1, a fibronectin receptor, is involved in endothelial cell migration and proliferation. Here we… Expand
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2006
2006
Integrin alpha(5)beta(1) plays an important role in developmental angiogenesis, but its role in various types of pathologic… Expand
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2006
2006
Integrin α 5 β 1 plays an important role in developmental angiogenesis, but its role in various types of pathologic… Expand
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