JP-1302

Ischemia/reperfusion injury is the most common cause of acute kidney injury. We previously revealed that pre-treatment with… Expand

Excitation of renal sympathetic nervous activity and the resulting increased levels of renal venous norepinephrine play important… Expand

The α2‐adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds… Expand

α2-Adrenoceptors were first described as presynaptic receptors inhibiting the release of various transmitters from neurons in the… Expand

BACKGROUND: A previous study from our laboratories showed that a significant reduction in spinal N-methyl-d-aspartate (NMDA… Expand

We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a… Expand

Dexmedetomidine is a highly specific, potent and selective α2‐adrenoceptor agonist. Although intrathecal and epidural… Expand

Indirect experimental evidence suggests that drugs acting on the α2C‐adrenoceptor could be useful in the treatment of… Expand

Pharmacological validation of novel functions for the α2A‐, α2B‐, and α2C‐adrenoceptor (AR) subtypes has been hampered by the… Expand

The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe… Expand