JP-1302

Excitation of renal sympathetic nervous activity and the resulting increased levels of renal venous norepinephrine play important… Expand

The α2-adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds… Expand

α2-Adrenoceptors were first described as presynaptic receptors inhibiting the release of various transmitters from neurons in the… Expand

BACKGROUND A previous study from our laboratories showed that a significant reduction in spinal N-methyl-D-aspartate (NMDA… Expand

Cooling-enhanced contractile responses in cutaneous arteries have been reported to involve the activation of alpha(2C… Expand

We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a… Expand

Dexmedetomidine is a highly specific, potent and selective alpha(2)-adrenoceptor agonist. Although intrathecal and epidural… Expand

Indirect experimental evidence suggests that drugs acting on the alpha(2C)-adrenoceptor could be useful in the treatment of… Expand

BACKGROUND AND PURPOSE Pharmacological validation of novel functions for the alpha2A-, alpha2B-, and alpha2C-adrenoceptor (AR… Expand

The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe… Expand