JP-1302

The α2-adrenoceptors (ARs) are important modulators of a wide array of physiological responses. As only a few selective compounds… (More)

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 90 years. So far, it is known that… (More)

BACKGROUND Blood vessels of the nasal mucosa are richly innervated by sympathetic nerves and neural mechanism is of great… (More)

BACKGROUND Nasal congestion is the most troublesome symptom associated with a variety of upper airway diseases, including… (More)

Cooling-enhanced contractile responses in cutaneous arteries have been reported to involve the activation of alpha(2C… (More)

We examined the effects of JP-1302 (a selective alpha2C antagonist), BRL-44408 (a selective alpha2A antagonist) and yohimbine (a… (More)

Dexmedetomidine is a highly specific, potent and selective alpha(2)-adrenoceptor agonist. Although intrathecal and epidural… (More)

Indirect experimental evidence suggests that drugs acting on the alpha(2C)-adrenoceptor could be useful in the treatment of… (More)

BACKGROUND AND PURPOSE Pharmacological validation of novel functions for the alpha2A-, alpha2B-, and alpha2C-adrenoceptor (AR… (More)

The discovery of JP-1302 as a selective, high affinity antagonist at the alpha2C-adrenoceptor will enable researchers to probe… (More)