Skip to search formSkip to main contentSkip to account menu

JNJ 7777120

Known as: JNJ7777120 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The Extracellular Loop 2 (ECL2) of the Human Histamine H4 Receptor Substantially Contributes to Ligand Binding and Constitutive Activity
In contrast to the corresponding mouse and rat orthologs, the human histamine H4 receptor (hH4R) shows extraordinarily high… 
2013
2013
Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis
The histamine H4 receptor has a primary role in inflammatory functions, making it an attractive target for the treatment of… 
Review
2012
Review
2012
Azines as histamine H4 receptor antagonists.
Since 2000, when the histamine H4 receptor (H4R) was cloned, it has constituted an interesting target for drug development… 
2011
2011
Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells
The histamine H4 receptor (H4R) is expressed on cells of the immune system including eosinophils, dendritic cells, and T cells… 
2011
2011
Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation
The histamine H4 receptor subtype (H4R) belongs to the class 1 of G protein-coupled receptors and is involved in inflammatory and… 
Highly Cited
2010
Highly Cited
2010
H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
Highly Cited
2009
Highly Cited
2009
Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
Many medicines exist which can cause pruritus (itching) as "serious adverse events." Many severe pruritic conditions respond… 
Highly Cited
2009
Highly Cited
2009
Histamine H4 receptor antagonism reduces hapten‐induced scratching behaviour but not inflammation
Abstract:  Effects of the histamine H4 receptor antagonist JNJ 7777120 (1‐[(5‐chloro‐1H‐indol‐2‐yl)carbonyl]‐4‐methylpiperazine… 
Highly Cited
2008
Highly Cited
2008
Histamine H4 receptors modulate dendritic cell migration through skin – immunomodulatory role of histamine
Background:  Dendritic cells (DC) are the major antigen‐presenting cells and play a key role in adaptive immunity as they are… 
2008
2008
Histamine‐induced actin polymerization in human eosinophils: An imaging approach for histamine H4 receptor
Image‐based screening, a new and flexible tool in the drug discovery cascade, is amenable to many different targets. This article… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)