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Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide.
TLDR
It is suggested that the combined administration of STZ and NA causes partial depletion of pancreatic insulin and that the high fat constituents lead to insulin resistance in this model. Expand
Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-α, and COX-2 expression in mouse macrophage RAW 264.7
TLDR
Examination of the inhibitory effects of the known oxycoumarins poncitrin, osthol, and xanthoxyletin, newly isolated from Clausena guillauminii, revealed that the synthesis of nitric oxide (NO) and the protein expression of tumor necrosis factor-α and cyclooxygenase-2 (COX-2) were inhibited by 5.7 μM. Expand
Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist.
TLDR
H4 receptor antagonists may be useful for treatment of H1 receptor antagonist-resistant pruritus, and their expression in human dermal fibroblasts is found to be greater in keratinocytes in the epidermal upper layer than in the lower layer. Expand
Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.
TLDR
Investigation of the relationship between the genotypes of drug-metabolizing enzymes involved in INH metabolism and the serum concentrations of INH and its metabolites in 129 tuberculosis patients hospitalizing in the National Hospital Organization Chiba-East Hospital found Hz tended to accumulate in patients with GST M1 null genotype. Expand
Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells.
TLDR
Findings suggest that sunitinib resistance involves multidrug resistance transporters, and in combination with elacridar, can be reversed in renal carcinoma cells by P-glycoprotein inhibition. Expand
Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model.
TLDR
Treatment with a H(4) receptor antagonist may be effective for amelioration of both skin inflammation and pruritus in patients with allergic dermatitis such as atopic dermatitis. Expand
A comparative study of histamine activities on differentiation of osteoblasts and osteoclasts.
TLDR
Results indicate that histamine induction of osteoclastogenesis is mediated by RANKL expressed via H(1)R, but notvia H(2)R in mouse osteoblast-like cells; and the major target of histamine action is the RankL-RANK signaling pathway in osteocytes. Expand
1α,25-Dihydroxyvitamin D3 inhibits neutrophil recruitment in hamster model of acute lung injury
TLDR
The findings show that vitamin D(3) analogues may be suitable as novel anti-inflammatory agents for ALI and inhibited neutrophil recruitment in the lung by approximately 40% without increasing plasma calcium concentration, while it did not inhibit monocyte recruitment. Expand
The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine.
TLDR
The results suggest that histamine is a potent inducer of osteoclast differentiation, at least in part, through the histamine H(2)-receptor, and cimetidine has a preventive effect on articular destruction and accompanying inflammation in arthritic rats. Expand
Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test
TLDR
It is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF, in a dose-dependent manner. Expand
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