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JIB-04

National Institutes of Health

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2 relations

Broader (2)

AminopyridinesHydrazones

Papers overview

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Highly Cited
2019
Highly Cited
2019
A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets.
2019
2019
Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells
Epigenetic modifiers were important players in the development of haematological malignancies and sensitivity to therapy… 
2019
2019
A CRISPR/Cas9 screen identifies the histone demethylase MINA53 as a novel HIV-1 latency-promoting gene (LPG)
Abstract Although combination antiretroviral therapy is potent to block active replication of HIV-1 in AIDS patients, HIV-1… 
Highly Cited
2018
Highly Cited
2018
Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks
2018
2018
JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway
Although several epigenetic modulating drugs are suggested to target cancer stem cells (CSCs), additional identification of anti… 
2018
2018
The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced…
Ewing Sarcoma is an aggressive malignant neoplasm affecting children and young adults. Ewing Sarcoma is driven by transcription… 
Highly Cited
2018
Highly Cited
2018
Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
Left ventricular hypertrophy (LVH) is a major risk factor for cardiovascular morbidity and mortality. Pathological LVH engages… 
Highly Cited
2017
Highly Cited
2017
SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia.
Mutations in SETD2, encoding the histone 3 lysine 36 trimethyltransferase, are enriched in relapsed acute lymphoblastic leukemia… 
2017
2017
The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding… 
2017
2017
Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL
Oxidized low density lipoprotein (oxLDL) induces macrophage activation, an event essential for atherosclerosis. Emerging evidence… 
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