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JAK2 Inhibitor

Any substance that inhibits JAK2 tyrosine protein kinase, an enzyme that phosphorylates the hydroxyl group of tyrosine on various proteins in various… 
National Institutes of Health

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Related topics

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Receptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Dual-functionality of RASSF1A overexpression in A375 cells is mediated by activation of IL-6/STAT3 regulatory loop
The RASSF1A, a microtubule associated protein, is a well-known tumor suppressor silenced in various cancer via promoter… 
2018
2018
Specific effects of neuregulin-1β on the communication between DRG neurons and skeletal muscle cells in vitro
The communication between primary afferent neuron and skeletal muscle (SKM) is one of the important factors on maintaining the… 
2016
2016
Inflammation and Inflammatory Mediators in Kidney Disease Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in renal proximal tubular cells
O’Leary R, Penrose H, Miyata K, Satou R. Macrophage-derived IL-6 contributes to ANG II-mediated angiotensinogen stimulation in… 
Review
2016
Review
2016
Hematopoietic stem cell transplantation and other therapeutic options in primary myelofibrosis: a review and two case reports
Primary myelofibrosis (PMF) is BCR/ABL–negative myeloproliferative disorder with splenomegaly, leukoerythroblasts, extramedullary… 
2014
2014
Piperlongumine Blocks JAK2-STAT3 Pathway to Inhibit Collagen-Induced Platelet Reactivity Independent of Reactive Oxygen Species
Piperlongumine (PL) from piper longum induces cancerous, but not normal cells to undergo reactive oxygen species (ROS)-mediated… 
2013
2013
Abstract 2435: Anticipating clinical resistance to SAR302503, a JAK2 inhibitor in clinical development for the treatment of myelofibrosis.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC One of the challenges of using kinase inhibitors in… 
Review
2012
Review
2012
Abstract P4-06-01: JAK2/STAT3 activity in inflammatory breast cancer supports the investigation of JAK2 therapeutic targeting
Background: Inflammatory breast cancer (IBC) is a virulent subtype of locally advanced breast cancer that accounts for 1–5% of… 
2010
2010
Bone marrow stroma-mediated paracrine inhibition of JAK2 inhibitor-induced apoptosis of JAK2V617F- mutated cells
Signals emanating from the bone marrow microenviroment are thought to support the survival and proliferation of the malignant… 
2008
2008
Successful Computational Prediction of the S tructure-Activity Relationship of a Potent JAK2 Inhibitor
JAK2 is a member of the JAK family of protein ty- rosine kinases (PTK). JAK2 is an important intracellular media- tor of cytokine… 
2006
2006
The effect of the JAK2 V617F mutation on PRV-1 expression.
JAK2(V617F)an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among…