JAK2 Inhibitor

Any substance that inhibits JAK2 tyrosine protein kinase, an enzyme that phosphorylates the hydroxyl group of tyrosine on various proteins in various… (More)
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND Dysregulated signaling of the JAK/STAT pathway is a common feature of chronic myeloproliferative neoplasms (MPN… (More)
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2013
2013
BACKGROUND Imatinib mesylate (IM) induces clinical remission of chronic myeloid leukemia (CML). The Abelson helper integration… (More)
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Highly Cited
2011
Highly Cited
2011
The identification of somatic activating mutations in JAK2 (refs 1–4) and in the thrombopoietin receptor gene (MPL) in most… (More)
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2010
2010
The discovery of JAK2 and MPL mutations in patients with myeloproliferative neoplasms (MPNs) provided important insight into the… (More)
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Highly Cited
2009
Highly Cited
2009
The mutant JAK2V617F tyrosine kinase (TK) is present in the majority of patients with BCR-ABL-negative myeloproliferative… (More)
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2008
2008
The Janus-associated kinase 2 (JAK2) V617F mutation is believed to play a critical role in the pathogenesis of polycythemia vera… (More)
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Highly Cited
2007
Highly Cited
2007
We report that TG101348, a selective small-molecule inhibitor of JAK2 with an in vitro IC50 of approximately 3 nM, shows… (More)
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Highly Cited
2007
Highly Cited
2007
Angiotensin (ANG) II exerts a negative modulation on insulin signal transduction that might be involved in the pathogenesis of… (More)
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Highly Cited
2006
Highly Cited
2006
We examined the role for the JAK/STAT signaling pathway in acute opioid-induced cardioprotection (OIC) and whether opioid-induced… (More)
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Highly Cited
2001
Highly Cited
2001
Advanced glycation end-product (AGE) is important in the pathogenesis of diabetic nephropathy (DN), and captopril (an angiotensin… (More)
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