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JAK2 Inhibitor

Any substance that inhibits JAK2 tyrosine protein kinase, an enzyme that phosphorylates the hydroxyl group of tyrosine on various proteins in various… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Objectives The programmed death ligand 1(PD‐L1)/programmed cell death protein 1 (PD‐1) pathway is one of the most important… Expand
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2014
2014
Aspirin-triggered Lipoxin A4 (ATL), as a Lipoxin A4 (LXA4) epimer, is endogenously produced by aspirin-acetylated cycloxygenase-2… Expand
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Highly Cited
2013
Highly Cited
2013
Background Dysregulated signaling of the JAK/STAT pathway is a common feature of chronic myeloproliferative neoplasms (MPN… Expand
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Highly Cited
2012
Highly Cited
2012
The identification of somatic activating mutations in JAK2 (refs 1–4) and in the thrombopoietin receptor gene (MPL) in most… Expand
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Highly Cited
2012
Highly Cited
2012
The JAK2/STAT3 signal pathway is an important component of survivor activating factor enhancement (SAFE) pathway. The objective… Expand
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Highly Cited
2010
Highly Cited
2010
The discovery of JAK2 and MPL mutations in patients with myeloproliferative neoplasms (MPNs) provided important insight into the… Expand
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Highly Cited
2009
Highly Cited
2009
The mutant JAK2V617F tyrosine kinase (TK) is present in the majority of patients with BCR-ABL-negative myeloproliferative… Expand
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Highly Cited
2008
Highly Cited
2008
We report that TG101348, a selective small-molecule inhibitor of JAK2 with an in vitro IC50 of approximately 3 nM, shows… Expand
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Highly Cited
2008
Highly Cited
2008
The Janus-associated kinase 2 (JAK2) V617F mutation is believed to play a critical role in the pathogenesis of polycythemia vera… Expand
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Highly Cited
2006
Highly Cited
2006
We examined the role for the JAK/STAT signaling pathway in acute opioid-induced cardioprotection (OIC) and whether opioid-induced… Expand
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