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Istaroxime
Known as:
3-((2-aminoethoxy)imino)androstane-6,17-dione
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (1)
Etiocholanolone
Narrower (1)
PST 2744
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Functional characterization and anti-cancer action of the clinical phase II cardiac Na+/K+ ATPase inhibitor istaroxime: in vitro and in vivo properties and cross talk with the membrane androgen…
K. Alevizopoulos
,
K. Dimas
,
+9 authors
C. Stournaras
OncoTarget
2016
Corpus ID: 20416909
Sodium potassium pump (Na+/K+ ATPase) is a validated pharmacological target for the treatment of various cardiac conditions…
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Review
2014
Review
2014
Novel drug targets in clinical development for heart failure
M. George
,
M. Rajaram
,
Elangovan Shanmugam
,
T. Vijayakumar
European Journal of Clinical Pharmacology
2014
Corpus ID: 18299745
Heart Failure continues to be a leading cause of mortality and morbidity worldwide. The dismal prognosis of patients in acute…
Expand
Review
2011
Review
2011
Newer Inotropes in Pediatric Heart Failure
T. M. Hoffman
Journal of Cardiovascular Pharmacology
2011
Corpus ID: 21223526
In the cardiac setting in pediatrics, inotropic support is often employed based on the extrapolation from adult studies, the…
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2011
2011
Chronic Istaroxime Improves Cardiac Function and Heart Rate Variability in Cardiomyopathic Hamsters
P. Lo Giudice
,
G. G. Mattera
,
J. Gagnol
,
F. Borsini
Cardiovascular Drugs and Therapy
2011
Corpus ID: 25587546
PurposeIstaroxime is a new luso-inotropic compound. It exerts inotropic action by reducing Na+/K+-ATPase activity, and…
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2011
2011
Istaroxime: Is the Remedy Better than the Disease?
D. Farmakis
,
G. Filippatos
Cardiovascular Drugs and Therapy
2011
Corpus ID: 36097834
Acute heart failure (AHF) is a condition with significant morbidity and mortality resulting in more than a million…
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2010
2010
Acute Heart Failure With Low Cardiac Output: Can We Develop a Short-term Inotropic Agent That Does Not Increase Adverse Events?
U. Campia
,
S. Nodari
,
M. Gheorghiade
Current Heart Failure Reports
2010
Corpus ID: 19168236
Acute heart failure represents an increasingly common cause of hospitalization, and may require the use of inotropic drugs in…
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Review
2008
Review
2008
New pharmacologic therapies for acute heart failure.
M. Tavares
,
E. Rezlan
,
I. Vostroknoutova
,
H. Khouadja
,
A. Mebazaa
Critical Care Medicine
2008
Corpus ID: 9639766
Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of…
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Highly Cited
2007
Highly Cited
2007
Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.
R. Micheletti
,
F. Palazzo
,
+7 authors
G. Bianchi
American Journal of Cardiology
2007
Corpus ID: 22649813
2007
2007
A phase 1-2 dose-escalating study evaluating the safety and tolerability of istaroxime and specific effects on electrocardiographic and hemodynamic parameters in patients with chronic heart failure…
J. Ghali
,
W. Smith
,
+8 authors
M. Gheorghiade
American Journal of Cardiology
2007
Corpus ID: 41546891
2007
2007
Targeting SERCA2a as an innovative approach to the therapy of congestive heart failure.
P. Ferrari
,
R. Micheletti
,
G. Valentini
,
G. Bianchi
Medical Hypotheses
2007
Corpus ID: 44967659
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