Isoflurane

Known as: 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether, 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, Isoflurane [Chemical/Ingredient] 
A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Remote ischemic preconditioning (RIPC) of the myocardium by limb ischemia/reperfusion may mitigate cardiac damage, but… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent brain, but susceptibility of non-human… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Neuroapoptosis is induced by the administration of anesthetic agents to the young. As alpha2 adrenoceptor signaling… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Exposure to anesthetics during synaptogenesis results in apoptosis and subsequent cognitive dysfunction in adulthood… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE An estimated 200 million patients worldwide have surgery each year. Anesthesia and surgery have been reported to… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Anesthetics, including isoflurane and nitrous oxide, an antagonist of the N-methyl-D-aspartate subtype of the… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Experimentally, isoflurane, a commonly used volatile anesthetic agent, mimics the cardioprotective effects of ischemic… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The authors tested the hypothesis that isoflurane directly preconditions myocardium against infarction via activation… (More)
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