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Isoflurane

Known as: 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether, 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, Isoflurane [Chemical/Ingredient] 
A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Background:Brief isoflurane anesthesia induces neuroapoptosis in the developing rodent brain, but susceptibility of non-human… 
Highly Cited
2009
Highly Cited
2009
Background:Neuroapoptosis is induced by the administration of anesthetic agents to the young. As α2 adrenoceptor signaling plays… 
Highly Cited
2009
Highly Cited
2009
Background:Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent… 
Highly Cited
2003
Highly Cited
2003
Recently it was demonstrated that exposure of the developing brain during the period of synaptogenesis to drugs that block NMDA… 
Highly Cited
2000
Highly Cited
2000
BackgroundLigand-gated ion channels are considered to be potential general anesthetic targets. Although most general anesthetics… 
Highly Cited
1999
Highly Cited
1999
BACKGROUND The effect of volatile anesthetics on cerebral blood flow depends on the balance between the indirect vasoconstrictive… 
Highly Cited
1997
Highly Cited
1997
Background: The bispectral index (BIS), a value derived from the electroencephalograph (EEG), has been proposed as a measure of… 
Highly Cited
1997
Highly Cited
1997
Background: The authors tested the hypothesis that isoflurane directly preconditions myocardium against infarction via activation… 
Highly Cited
1996
Highly Cited
1996
Background Remifentanil is a new micro‐specific opioid receptor agonist currently under investigation. The interaction between… 
Highly Cited
1995
Highly Cited
1995
Background Although inhalation anesthetic agents are thought to impair cerebral autoregulation more than intravenous agents…