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Isoaspartate

Known as: beta Aspartate, beta-Aspartate 
National Institutes of Health

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Isoaspartic Acid

Papers overview

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2013
2013
Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation.
Mutations within the Aβ (amyloid β) peptide, especially those clustered at residues 21-23, are linked to early-onset AD… 
2010
2010
Probing deamidation in therapeutic immunoglobulin gamma (IgG1) by 'bottom-up' mass spectrometry with electron transfer dissociation.
Aspartic acid formed by nonenzymatic deamidation of asparagine often isomerizes to isoaspartic acid through a succinimide… 
2008
2008
Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential β-secretases
Abstract Neuritic plaques of Alzheimer patients are composed of multiple protein components. Among them, the amyloid β-peptides… 
2005
2005
Protein Isoaspartate Methyltransferase Is a Multicopy Suppressor of Protein Aggregation in Escherichia coli
ABSTRACT We used preS2-S′-β-galactosidase, a three-domain fusion protein that aggregates extensively at 43°C in the cytoplasm of… 
2000
2000
Analysis of isoaspartate in peptides and proteins without the use of radioisotopes.
A rapid and sensitive HPLC-based method for quantitating isoaspartate levels in peptides and proteins is described. The analyte… 
Highly Cited
1999
Highly Cited
1999
Formation of four isomers at the asp-151 residue of aged human alphaA-crystallin by natural aging.
Although proteins are generally composed entirely of l-amino acids, we have previously shown that Asp-151 in alphaA-crystallin… 
Highly Cited
1998
Highly Cited
1998
Selective deamidation of recombinant human stem cell factor during in vitro aging: isolation and characterization of the aspartyl and isoaspartyl homodimers and heterodimers.
During in vitro aging, deamidation of recombinant human stem cell factor produced in Escherichia. coli was detected by HPLC… 
1993
1993
Protein sorting by high-performance liquid chromatography. I. Biomimetic interaction chromatography of recombinant human deoxyribonuclease I on polyionic stationary phases.
1990
1990
Formation of isoaspartate 99 in bovine and porcine somatotropins
Asparagine 99 in bovine (BST) and porcine somatotropins (PST) was converted to an isoaspartate residue during incubation at… 
1990
1990
Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor.
Long-term storage of recombinant human epidermal growth factor (EGF), an important promoter of cell division, results in its… 
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