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Iso-fludelone

Known as: 17-Iso-oxazole-26-F3-9,10-dehydro-12,13-desoxy-epothilone B, 17-Iso-oxazole-fludelone 
A third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces… 
National Institutes of Health

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KOS-1803
Microtubule ProcessNegative Regulation of G2 to M TransitionNegative Regulation of Microtubule DepolymerizationNegative Regulation of Mitosis

Papers overview

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2011
2011
Abstract 3527: Therapeutic cure against five human xenograft tumors and strongly suppressed drug-resistant and refractory xenograft tumors in nude mice by the third generation epothilone: Iso-oxazole…
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Iso-oxazole fludelone (Iso-flu) is a 16-member ring… 
2011
2011
Abstract 3521: Alleviation of cancer chemotherapeutic agent-induced toxicity by the synthetic panaxytriol analogues of Panax Ginseng
Therapeutic index (TI) of cancer therapeutic agent is the ratio of maximal tolerated dose (MTD) and the optimal therapeutic dose… 
2009
2009
Abstract #5565: The therapeutic effects against refractory and multiple drug resistant xenograft tumors by the third generation microtubule targeting epothilone: Iso-oxazole-fludelone
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO Epothilones, 16-member ring macrolides, originally isolated from myxobacterium… 
2005
2005
Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo.
26-Trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B [Fludelone (Flu)] has shown broad antitumor activity in solid tumor models… 
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