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Iron Regulatory Protein 1

Known as: Ferritin Repressor Protein, ACO1 Protein, Aconitase 1, Soluble 
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron… 
National Institutes of Health

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ACO1 geneIn BloodProcess of secretionagonists

Papers overview

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Review
2018
Review
2018
Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. However, therapeutic options treating only its… 
Review
2018
Review
2018
Update on Immunohistochemistry for the Diagnosis of Lung Cancer
Immunohistochemistry is a widely available technique that is less challenging and can provide clinically meaningful results… 
Highly Cited
2005
Highly Cited
2005
Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.
The studies described herein were designed to investigate the effects of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside… 
Highly Cited
2005
Highly Cited
2005
Long-Term Treatment of Bile Duct-Ligated Rats with Rapamycin (Sirolimus) Significantly Attenuates Liver Fibrosis: Analysis of the Underlying Mechanisms
Rapamycin is an immunosuppressant with antiproliferative properties. We investigated whether rapamycin treatment of bile duct… 
Highly Cited
2002
Highly Cited
2002
Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif
ABSTRACT Eukaryotic initiation factor 4E (eIF4E) binding proteins (4E-BPs) regulate the assembly of initiation complexes required… 
Highly Cited
1999
Highly Cited
1999
Human Cytoplasmic Aconitase (Iron Regulatory Protein 1) Is Converted into Its [3Fe-4S] Form by Hydrogen Peroxide in Vitro but Is Not Activated for Iron-responsive Element Binding*
Iron regulatory protein 1 (IRP1) regulates the synthesis of proteins involved in iron homeostasis by binding to iron-responsive… 
Highly Cited
1998
Highly Cited
1998
Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthesis by Amino Acids in L6 Myoblasts*
The present study was designed to investigate the mechanism through which leucine and histidine regulate translation initiation… 
Highly Cited
1996
Highly Cited
1996
Structure and expression of three genes encoding ACC oxidase homologs from melon (Cucumis melo L.)
The enzyme ACC oxidase catalyses the last step of ethylene biosynthesis in plants, converting 1-aminocyclopropane-1-carboxylic… 
Highly Cited
1993
Highly Cited
1993
The pathogenesis of superficial siderosis of the central nervous system
In advanced cases of superficial siderosis of the human central nervous system, the clinical triad of hearing loss, cerebellar… 
Highly Cited
1993
Highly Cited
1993
Automated docking in crystallography: Analysis of the substrates of aconitase
Automated docking of substrates to proteins of known structure aids the process of crystallographic analysis in two ways. First… 
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