Ionomycin

Known as: IONO, Ionomycin [Chemical/Ingredient] 
A polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in response to metabolic stress and to… (More)
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Highly Cited
2004
Highly Cited
2004
Today, quantitative real-time PCR is the method of choice for rapid and reliable quantification of mRNA transcription. However… (More)
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Highly Cited
2002
Highly Cited
2002
Ubiquitous calpains (mu- and m-calpain) have been repeatedly implicated in apoptosis, but the underlying mechanism(s) remain(s… (More)
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Highly Cited
2002
Highly Cited
2002
T helper type 1 (TH1) cell development involves interferon-γ (IFN-γ) signaling through signal transducer and activator of… (More)
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Highly Cited
2002
Highly Cited
2002
CD1d-restricted natural killer (NK)T cells are known to potently secrete T helper (Th)1 and Th2 cytokines and to mediate… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P2) pools that bind pleckstrin homology (PH) domains were visualized by… (More)
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Highly Cited
1994
Highly Cited
1994
In fura-2-loaded ECV304 cells ionomycin elicited a saturable biphasic change in intracellular Ca2+ concentration ([Ca2+]i), where… (More)
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Highly Cited
1992
Highly Cited
1992
IN many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane1–3… (More)
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Highly Cited
1989
Highly Cited
1989
We have investigated signaling mechanisms that may underlie the T cell mitogenic properties of the Ca2+ ionophore ionomycin… (More)
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Highly Cited
1978
Highly Cited
1978
The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of… (More)
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