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Interferon beta-1a

Known as: Interferon.beta 1a, beta 1a, Interferon, IFN-beta 
An interferon beta-1 subtype that has a methionine at position 1, a cysteine at position 17, and is glycosylated at position 80. It functions as an… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (3)

Antineoplastic AgentsAntiviral AgentsImmunologic Adjuvants

Narrower (3)

AvonexInterferon beta-1a 0.03 MG InjectionRebif
Avonex PenDrug AllergyIFNB1 geneIn Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Human Cytomegalovirus IE86 Attenuates Virus- and Tumor Necrosis Factor Alpha-Induced NFκB-Dependent Gene Expression
ABSTRACT Human cytomegalovirus (HCMV) infection regulates a number of genes involved in the host antiviral response. We have… 
Highly Cited
2005
Highly Cited
2005
TLR4 and Toll-IL-1 Receptor Domain-Containing Adapter-Inducing IFN-β, but Not MyD88, Regulate Escherichia coli-Induced Dendritic Cell Maturation and Apoptosis In Vivo1
Dendritic cells (DC) are short-lived, professional APCs that play a central role in the generation of adaptive immune responses… 
Highly Cited
1999
Highly Cited
1999
Inhibition of T cell apoptosis by IFN‐β rapidly reverses nuclear translocation of protein kinase C‐δ
Type I interferons rescue activated human T cells from cytokine deprivation‐induced apoptosis. Our data now show that IFN‐β also… 
Review
1998
Review
1998
IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic…
Highly Cited
1997
Highly Cited
1997
The vesicular stomatitis virus matrix protein inhibits transcription from the human beta interferon promoter
In cells infected by wild-type (wt) vesicular stomatitis virus (VSV) Indiana, host transcription is severely inhibited. DNA… 
Highly Cited
1996
Highly Cited
1996
Circulating serum levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to…
Interleukin (IL)-1 receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 which binds to IL-1 receptors without… 
Highly Cited
1990
Highly Cited
1990
The human intracellular Mx‐homologous protein is specifically induced by type I interferons
The murine Mx‐1 protein is one of the best biochemically and functionally characterized interferon (IFN)‐induced proteins that is… 
Highly Cited
1985
Highly Cited
1985
Induction of a 26-kDa-protein mRNA in human cells treated with an interleukin-1-related, leukocyte-derived factor.
A human-leukocyte-derived antiviral protein (22-kDa factor), known to be an inducer of interferon-beta (IFN-beta) in… 
Highly Cited
1985
Highly Cited
1985
Interferon regulates c-myc gene expression in Daudi cells at the post-transcriptional level.
c-myc gene mRNA is reduced by greater than 75% in the human lymphoblastoid cell line Daudi when growth is inhibited by treatment… 
Highly Cited
1982
Highly Cited
1982
Increased synthesis in E. coli of fibroblast and leukocyte interferons through alterations in ribosome binding sites.
Eleven chimeric plasmids have been constructed which direct the synthesis of mature human fibroblast (IFN-beta 1) or leukocyte… 
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