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Integrin alpha6beta4

Known as: A9 Antigen, alpha6beta4, Integrin, alpha6 beta4 Integrin 
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is… 
National Institutes of Health

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In BloodIntegrin alpha6agonistsantagonists & inhibitors

Papers overview

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Highly Cited
2009
Highly Cited
2009
Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly.
Hemidesmosomes (HDs) are multiprotein structures that anchor epithelial cells to the basement membrane. HD components include the… 
2007
2007
Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression.
Pancreatic adenocarcinomas are highly invasive cancers for reasons that are currently unclear. Here we sought to determine if the… 
2006
2006
Laminin 5 Regulates Polycystic Kidney Cell Proliferation and Cyst Formation*
Renal cyst formation is the hallmark of autosomal dominant polycystic kidney disease (ADPKD). ADPKD cyst-lining cells have an… 
2005
2005
Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes.
Keratinocyte integrins alpha6beta4 and alpha3beta1 bind laminin-5, a component of basement membranes. We previously demonstrated… 
Highly Cited
2000
Highly Cited
2000
Laminin alpha4 and integrin alpha6 are upregulated in regenerating dy/dy skeletal muscle: comparative expression of laminin and integrin isoforms in muscles regenerating after crush injury.
The expression of laminin isoforms and laminin-binding integrin receptors known to occur in muscle was investigated during… 
1989
1989
Ligand-induced phosphorylation of a murine tumor surface protein (TSP-180) associated with metastatic phenotype.
A tumor surface protein (TSP-180) has been identified on murine lung carcinomas using two monoclonal antibodies (MoAbs) (135-13C… 
Highly Cited
1988
Highly Cited
1988
Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue.
We have identified and quantitated a tumor protein complex, TSP-180, on murine carcinomas with two monoclonal antibodies (MoAbs… 
1987
1987
Expression of A9 Antigen and Loss of Blood Group Antigens as Determinants of Survival in Patients with Head and Neck Squamous Carcinoma
The murine monoclonal antibody (A9), raised to the human squamous cell carcinoma (SCC) cell-line UM-SCC-1, defines a squamous… 
1986
1986
Tumor antigen on benign adenomas and on murine lung carcinomas quantitated by a two-site monoclonal antibody assay.
TSP-180 is a Mr 180,000 cell surface protein found on several murine lung carcinomas but not on fibroblast or sarcoma cell lines… 
Highly Cited
1981
Highly Cited
1981
Analysis of surface proteins of mouse lung carcinomas using monoclonal antibodies.
Hybridoma cultures secreting monoclonal antibodies were derived from fusions of parent myeloma P3-X63-Ag8 with spleen cells of… 
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