Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression.

@article{CruzMonserrate2007UpregulationAR,
  title={Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression.},
  author={Zobeida Cruz-Monserrate and Suimin Qiu and Bernard Mark Evers and Kathleen L O'connor},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={2007},
  volume={20 6},
  pages={656-67}
}
Pancreatic adenocarcinomas are highly invasive cancers for reasons that are currently unclear. Here we sought to determine if the proinvasive integrin alpha6beta4 may be related to pancreatic adenocarcinoma tumor progression. Expression of integrin alpha6beta4 was analyzed via immunohistochemistry for the beta4 subunit in normal pancreas, pancreatic intraepithelial neoplasia (PanIN) lesions, pancreatic adenocarcinomas and chronic pancreatitis. In normal pancreatic ducts, integrin alpha6beta4… CONTINUE READING

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