Integrase Inhibitors

Known as: Inhibitors, Integrase, integrase inhibitor 
Compounds which inhibit or antagonize biosynthesis or actions of integrase.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Dolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable… (More)
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Highly Cited
2011
Highly Cited
2011
S/GSK1349572 is a next-generation HIV integrase (IN) inhibitor designed to deliver potent antiviral activity with a low-milligram… (More)
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Highly Cited
2010
Highly Cited
2010
S/GSK1349572 is a novel integrase inhibitor with potent in vitro anti-HIV activity, an in vitro resistance profile different from… (More)
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Highly Cited
2008
Highly Cited
2008
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and… (More)
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Highly Cited
2008
Highly Cited
2008
Integration of viral DNA into the host chromosome is an essential step in the life cycle of retroviruses and is facilitated by… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Raltegravir (MK-0518) is an HIV-1 integrase inhibitor with potent in-vitro activity against HIV-1 strains including… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Raltegravir (MK-0518) belongs to the new class of HIV integrase inhibitors. To date, there have been no reports… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Two inhibitors of the HIV-1 integrase enzyme (INIs) are in late stage clinical development. To date, approximately 42… (More)
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Highly Cited
2006
Highly Cited
2006
The viral enzyme integrase is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents a… (More)
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Highly Cited
2004
Highly Cited
2004
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human… (More)
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