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Ineffective erythropoiesis

Known as: Defective erythropoiesis 
 
National Institutes of Health

Related topics

Related topics

6 relations
5q-syndromeANEMIA, CONGENITAL DYSERYTHROPOIETIC, TYPE IVCongenital dyserythropoietic anemia, type IIHYPERBILIRUBINEMIA, SHUNT, PRIMARY
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Broader (1)

Dyserythropoiesis

Papers overview

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Review
2017
Review
2017
Ineffective Erythropoiesis: Anemia and Iron Overload.
Stress erythropoiesis (SE) is characterized by an imbalance in erythroid proliferation and differentiation under increased… Expand
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2014
2014
Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia.
In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late… Expand
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2014
2014
Erythropoiesis-driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15.
Growth differentiation factor 15 (GDF-15) is a bone marrow-derived cytokine whose ability to suppress iron regulator hepcidin in… Expand
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Review
2014
Review
2014
Sideroblastic anemia: diagnosis and management.
Sideroblastic anemias (SAs) may be acquired or congenital and share the features of disrupted utilization of iron in the… Expand
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Highly Cited
2013
Highly Cited
2013
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are… Expand
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2010
2010
β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
beta-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of beta-globin. The defects… Expand
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Review
2009
Review
2009
Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease.
The pathophysiological consequences of transfusional iron overload largely reflect the pattern of excess iron distribution and… Expand
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2009
2009
Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Iron Absorption in Mice Affected by β-Thalassemia and Other Disorders of Red Cell Production.
Abstract 2020 Poster Board I-1042 β-thalassemia intermedia (TI) and major (TM) are characterized by Ineffective Erythropoiesis… Expand
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Highly Cited
2008
Highly Cited
2008
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
In beta-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice… Expand
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Highly Cited
2007
Highly Cited
2007
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known… Expand
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