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Ineffective erythropoiesis

Known as: Defective erythropoiesis 
National Institutes of Health

Related topics

Related topics

6 relations
5q-syndromeANEMIA, CONGENITAL DYSERYTHROPOIETIC, TYPE IVCongenital dyserythropoietic anemia, type IIHYPERBILIRUBINEMIA, SHUNT, PRIMARY

Broader (1)

Dyserythropoiesis

Papers overview

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Review
2019
Review
2019
Iron metabolism under conditions of ineffective erythropoiesis in β-thalassemia.
β-Thalassemia (BT) is an inherited genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia… 
Review
2018
Review
2018
Ineffective Erythropoiesis: Anemia and Iron Overload.
Highly Cited
2014
Highly Cited
2014
Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia.
In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late… 
Review
2014
Review
2014
Sideroblastic anemia: diagnosis and management.
Review
2014
Review
2014
Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.
Highly Cited
2013
Highly Cited
2013
Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are… 
Highly Cited
2010
Highly Cited
2010
β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
β-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of β-globin. The defects involved… 
Highly Cited
2008
Highly Cited
2008
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
In beta-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice… 
Highly Cited
2007
Highly Cited
2007
Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known… 
1962
1962
Anæmia and Polycythæmia with Renal Disease
Red Cell Morphology in Renal Anemia In early studies by Ashe (1929) and Parsons and Ekola-Strolberg (I933) the anlemia was found… 
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