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β-Thalassemia (BT) is an inherited genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia… Expand Stress erythropoiesis (SE) is characterized by an imbalance in erythroid proliferation and differentiation under increased… Expand In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late… Expand Sideroblastic anemias (SAs) may be acquired or congenital and share the features of disrupted utilization of iron in the… Expand β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are… Expand β-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of β-globin. The defects involved… Expand The pathophysiological consequences of transfusional iron overload largely reflect the pattern of excess iron distribution and… Expand In beta-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice… Expand Progressive iron overload is the most salient and ultimately fatal complication of beta-thalassemia. However, little is known… Expand Red Cell Morphology in Renal Anemia In early studies by Ashe (1929) and Parsons and Ekola-Strolberg (I933) the anlemia was found… Expand