Sideroblastic anemia: diagnosis and management.

  title={Sideroblastic anemia: diagnosis and management.},
  author={Sylvia S. Bottomley and Mark D Fleming},
  journal={Hematology/oncology clinics of North America},
  volume={28 4},
  pages={653-70, v}
Sideroblastic anemias (SAs) may be acquired or congenital and share the features of disrupted utilization of iron in the erythroblast, ineffective erythropoiesis, and variable systemic iron overload. Congenital forms can have associated syndromic features or be nonsyndromic, and many of them have mutations in genes encoding proteins involved in heme biosynthesis, iron-sulfur cluster biogenesis, or mitochondrial protein synthesis. The mechanism(s) for the acquired clonal SA is undefined and is… CONTINUE READING