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Inactivation, Metabolic

Known as: Metabolic Inactivation 
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected… Expand
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Highly Cited
2008
Highly Cited
2008
Resistance towards anticancer drugs is a general problem upon chemotherapy. Among the mechanisms of resistance, metabolic… Expand
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Highly Cited
2007
Highly Cited
2007
Anandamide is an endogenous ligand for brain cannabinoid CB1 receptors, but its behavioral effects are difficult to measure due… Expand
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2007
2007
Hydroxamic acid (HA)-based histone deacetylase (HDAC) inhibitors, with trichostatin A (TSA) as the reference compound, are… Expand
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2007
2007
Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4… Expand
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2005
2005
In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine… Expand
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Review
2003
Review
2003
Vitamin B12 deficiency is a common but under-recognized, yet easily treatable disorder in older adults. Although several causes… Expand
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Highly Cited
1996
Highly Cited
1996
There are at least four subtypes of prostaglandin E (PGE) receptors. The EP1 and EP3 receptors are coupled to Ca2+ mobilization… Expand
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Highly Cited
1995
Highly Cited
1995
Arachidonoylethanolamide or 'anandamide' is a naturally occurring derivative of arachidonic acid that has been shown to activate… Expand
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Review
1981
Review
1981
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an… Expand
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