Inactivation, Metabolic

Known as: Metabolic Inactivation 
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1961-2017
0102019612017

Papers overview

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2013
2013
Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in… (More)
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2010
2010
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected… (More)
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2008
2008
Resistance towards anticancer drugs is a general problem upon chemotherapy. Among the mechanisms of resistance, metabolic… (More)
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2008
2008
Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is a potent anti-inflammatory and proresolving… (More)
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2006
2006
The resolvins (Rv) are lipid mediators derived from omega-3 polyunsaturated fatty acids that act within a local inflammatory… (More)
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Highly Cited
2004
Highly Cited
2004
Genetically variable CYP2A6 is the primary enzyme that inactivates nicotine to cotinine. Our objective was to investigate allele… (More)
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Highly Cited
2003
Highly Cited
2003
Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic… (More)
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2000
2000
The lipoxins (LX) are autacoids that act within a local inflammatory milieu to dampen neutrophil recruitment and promote… (More)
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1996
1996
There are at least four subtypes of prostaglandin E (PGE) receptors. The EP1 and EP3 receptors are coupled to Ca2+ mobilization… (More)
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Highly Cited
1994
Highly Cited
1994
Quercetin is highly mutagenic in vitro, yet is not carcinogenic when administered chronically at large doses to rodents for 12… (More)
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