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Inactivation, Metabolic

Known as: Metabolic Inactivation 
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes… 
National Institutes of Health

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Metabolic Detoxication, Drug
aspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Phase II drug metabolizing enzymes.
BACKGROUND Phase II biotransformation reactions (also 'conjugation reactions') generally serve as a detoxifying step in drug… 
Highly Cited
2010
Highly Cited
2010
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected… 
Highly Cited
2008
Highly Cited
2008
Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3.
2007
2007
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
Highly Cited
2005
Highly Cited
2005
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
Review
2003
Review
2003
Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.
Vitamin B12 deficiency is a common but under-recognized, yet easily treatable disorder in older adults. Although several causes… 
Highly Cited
1996
Highly Cited
1996
Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.
There are at least four subtypes of prostaglandin E (PGE) receptors. The EP1 and EP3 receptors are coupled to Ca2+ mobilization… 
Highly Cited
1995
Highly Cited
1995
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain.
Review
1981
Review
1981
Pharmacology of midazolam.
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an… 
1967
1967
Calcium transport in isolated guinea-pig atria during metabolic inhibition.
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