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Inactivation, Metabolic

Known as: Metabolic Inactivation 
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes… Expand
National Institutes of Health

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Metabolic Detoxication, Drug
aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2010
Highly Cited
2010
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected… Expand
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Highly Cited
2008
Highly Cited
2008
Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3.
Resistance towards anticancer drugs is a general problem upon chemotherapy. Among the mechanisms of resistance, metabolic… Expand
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Highly Cited
2007
Highly Cited
2007
The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by…
Anandamide is an endogenous ligand for brain cannabinoid CB1 receptors, but its behavioral effects are difficult to measure due… Expand
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2007
2007
A Metabolic Screening Study of Trichostatin A (TSA) and TSA-Like Histone Deacetylase Inhibitors in Rat and Human Primary Hepatocyte Cultures
Hydroxamic acid (HA)-based histone deacetylase (HDAC) inhibitors, with trichostatin A (TSA) as the reference compound, are… Expand
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2007
2007
Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities.
Lipoxins are a group of biologically active eicosanoids typically formed by transcellular lipoxygenase activity. Lipoxin A4 (LXA4… Expand
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2005
2005
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine… Expand
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Review
2003
Review
2003
Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.
Vitamin B12 deficiency is a common but under-recognized, yet easily treatable disorder in older adults. Although several causes… Expand
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Highly Cited
1996
Highly Cited
1996
Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.
There are at least four subtypes of prostaglandin E (PGE) receptors. The EP1 and EP3 receptors are coupled to Ca2+ mobilization… Expand
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Highly Cited
1995
Highly Cited
1995
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain.
Arachidonoylethanolamide or 'anandamide' is a naturally occurring derivative of arachidonic acid that has been shown to activate… Expand
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Review
1981
Review
1981
Pharmacology of midazolam.
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an… Expand
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