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Inactivation, Metabolic
Known as:
Metabolic Inactivation
Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes…
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National Institutes of Health
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Related topics
Related topics
3 relations
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Metabolic Detoxication, Drug
aspects of radiation effects
physiological aspects
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Phase II drug metabolizing enzymes.
P. Jančová
,
P. Anzenbacher
,
E. Anzenbacherová
Biomedical papers of the Medical Faculty of the…
2010
Corpus ID: 31134090
BACKGROUND Phase II biotransformation reactions (also 'conjugation reactions') generally serve as a detoxifying step in drug…
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Highly Cited
2010
Highly Cited
2010
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
P. Procopiou
,
V. Barrett
,
+18 authors
P. Tomlin
Journal of Medicinal Chemistry
2010
Corpus ID: 24132429
A series of saligenin beta(2) adrenoceptor agonist antedrugs having high clearance were prepared by reacting a protected…
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Highly Cited
2008
Highly Cited
2008
Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3.
R. Novotná
,
V. Wsól
,
G. Xiong
,
E. Maser
Toxicology Letters
2008
Corpus ID: 33860922
2007
2007
Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
J. Prusakiewicz
,
Melissa V. Turman
,
+4 authors
L. Marnett
Archives of Biochemistry and Biophysics
2007
Corpus ID: 45534562
Highly Cited
2005
Highly Cited
2005
Structural basis for inhibition of histamine N-methyltransferase by diverse drugs.
J. Horton
,
K. Sawada
,
M. Nishibori
,
Xiaodong Cheng
Journal of Molecular Biology
2005
Corpus ID: 37730546
Review
2003
Review
2003
Vitamin B12 deficiency. Recognizing subtle symptoms in older adults.
T. Dharmarajan
,
G. Adiga
,
E. Norkus
Geriatrics
2003
Corpus ID: 22327094
Vitamin B12 deficiency is a common but under-recognized, yet easily treatable disorder in older adults. Although several causes…
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Highly Cited
1996
Highly Cited
1996
Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.
N. Nishigaki
,
M. Negishi
,
A. Ichikawa
Molecular Pharmacology
1996
Corpus ID: 8692069
There are at least four subtypes of prostaglandin E (PGE) receptors. The EP1 and EP3 receptors are coupled to Ca2+ mobilization…
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Highly Cited
1995
Highly Cited
1995
Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain.
C. Hillard
,
D. Wilkison
,
W. Edgemond
,
W. Campbell
Biochimica et Biophysica Acta
1995
Corpus ID: 13420600
Review
1981
Review
1981
Pharmacology of midazolam.
L. Pieri
,
R. Schaffner
,
+13 authors
W. Haefely
Arzneimittel-Forschung
1981
Corpus ID: 38544096
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) is an…
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1967
1967
Calcium transport in isolated guinea-pig atria during metabolic inhibition.
H. Lahrtz
,
H. Lüllmann
,
P. V. van Zwieten
Biochimica et Biophysica Acta
1967
Corpus ID: 26353233
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