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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy.
It is found that cardiac fibroblasts secrete star miRNA-enriched exosomes and fibroblast-derived miR-21* is identified as a paracrine signaling mediator of cardiomyocyte hypertrophy that has potential as a therapeutic target.
Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure
LIPCAR levels identified patients developing cardiac remodeling and were independently to other risk markers associated with future cardiovascular deaths and predicts future death in patients with heart failure.
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
The data suggest that the production of ADMA by human endothelial cells is regulated by S-adenosylmethionine-dependent methyltransferases, which may be due in part to the enhanced gene expression of PRMTs.
Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes
Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O2−) formation instead ofNitric oxide (NO) causes diabetic endothelial dysfunction and subsequent reduction of EPC levels and impairment of E PC function likely contributes to the pathogenesis of vascular disease in diabetes.
Circulating micrornas as potential biomarkers of aerobic exercise capacity
- F. Mooren, J. Viereck, K. Krüger, T. Thum
- BiologyAmerican journal of physiology. Heart and…
- 20 December 2013
A potential role for muscle- and heart-specific miRs in cardiovascular adaptation processes after endurance exercise is suggested and their relation to conventional biochemical, cardiovascular, and performance indexes are analyzed.
Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome.
MicroRNA-24 Regulates Vascularity After Myocardial Infarction
It is shown that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia, and is suitable for therapeutic intervention in the setting of ischemic heart disease.
Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled,…