IgM B cell receptor complex

Known as: IgM B cell receptor complex location, surface IgM 
An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the… (More)
National Institutes of Health

Papers overview

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2013
2013
Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function.
Chronic lymphocytic leukemia (CLL) is a tumor of circulating B cells, variably stimulated and anergized following exposure to… (More)
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2011
2011
Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.
B cell anergy represents an important mechanism of peripheral immunological tolerance for mature autoreactive B cells that escape… (More)
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2005
2005
B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients.
On the basis of responses to surface IgM (sIgM) cross-linking, B cells from 41 patients with B-chronic lymphocytic leukemia were… (More)
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2004
2004
Clonotypic IgM V/D/J sequence analysis in Waldenstrom macroglobulinemia suggests an unusual B-cell origin and an expansion of polyclonal B cells in peripheral blood.
Analysis of clonotypic immunoglobulin M (IgM) from 15 patients with Waldenstrom macroglobulinemia (WM) showed a strong… (More)
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1998
1998
Long-lived B cells are distinguished by elevated expression of A1.
Only 5% of the 15 million B cells formed daily reach the long-lived peripheral B cell pool, presumably reflecting both negative… (More)
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Highly Cited
1998
Highly Cited
1998
CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu…
IgA are major effectors of antimicrobial defense in the respiratory and digestive tracts. We have analyzed the requirements for… (More)
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Highly Cited
1995
Highly Cited
1995
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis
Surface IgM (sIgM) stimulation induces the tyrosine phosphorylation of multiple cellular substrates, including phospholipase C… (More)
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Highly Cited
1995
Highly Cited
1995
Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells.
The B cell surface antigen receptor, surface IgM (sIgM), is involved in B cell activation and proliferation. CD40 is involved in… (More)
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Highly Cited
1993
Highly Cited
1993
CD22 associates with the human surface IgM-B-cell antigen receptor complex.
The B-cell surface molecule CD22, when cross-linked, modulates signaling through the surface IgM (sIgM)-B-cell receptor (BCR… (More)
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Highly Cited
1982
Highly Cited
1982
Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes.
Two leukemic cell lines (697 and 207) were established from bone marrow cells obtained from children with ALL in relapse. These… (More)
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